Eccentric correction of piston based on bionic micro-texture technology for the gap seal hydraulic cylinder

Micro & nano letters

article

Xiaolan Chen¹  Liangcai Zeng¹  Xiaobo Chen² 

[1] Key Laboratory of Metallurgical Equipment and Control of Ministry of Education, Wuhan University of Science and Technology;College of Mechanical and Electrical Engineering, Huanggang Normal University;Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering, Wuhan University of Science and Technology

关键词: friction;    hydraulic systems;    pistons;    biomimetics;    design engineering;    surface texture;    casting;    deformation;    gap seal hydraulic cylinder;    continuous casting machine;    internal leakage;    friction pair;    serious consequences;    deformation failure;    microtexture technology;    continuous centring force;    piston eccentricity;    hydraulic cylinder operating parameters;    biomimetic microtexture parameters;    dynamic pressure support force;    hydraulic system;    eccentric correction;   

DOI  :  10.1049/mnl.2018.5102

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The aim of the present study was to develop theophylline (TP) inhalable sustained delivery system by preparing solid lipid microparticles using glyceryl behenate (GB) and poloxamer 188 (PX) as a lipid carrier and a surfactant respectively. The method involves loading TP nanoparticles into the lipid using high shear homogenization – ultrasonication technique followed by lyophilization. The compositional variations and interactions were evaluated using response surface methodology, a Box – Behnken design of experiment (DOE). The DOE constructed using TP (X1), GB (X2) and PX (X3) levels as independent factors. Responses measured were the entrapment efficiency (% EE) (Y1), mass median aerodynamic diameter (MMAD, daer) (Y2), zeta potential (ZP, ξ) (Y3), fine particles fraction (% FPF) (Y4) and percentage of dissolution efficiency at 420 minutes (% DE420) (Y5). The optimized formula was characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X – ray powder diffraction (XRD) demonstrated that prolonged release physically due to the loaded TP exists mostly in its crystalline state . Analysis of dissolution data of the optimized formula indicated that the best fitting is with Higuchi model, whereas the mechanism of drug release pattern follows anomalous or non – Fickian diffusion.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND