Enhanced bactericidal activity of azithromycin-coated silver nanoprisms in comparison to their spherical-shaped counterparts

Micro & nano letters

article

Atif Yaqub¹  Sharafat Ali¹  Sarwar Allah Ditta¹  Fouzia Tanvir¹  Shaista Ali²  Misbah Naz² 

[1] Department of Zoology, Government College University;Department of Chemistry, Government College University

关键词: visible spectra;    nanoparticles;    biochemistry;    transmission electron microscopy;    ultraviolet spectra;    silver;    molecular biophysics;    particle size;    microorganisms;    nanomedicine;    nanofabrication;    biomedical materials;    antibacterial activity;    Fourier transform infrared spectra;    cellular biophysics;    dynamic transmission electron microscopy;    spherical nanoparticles;    prismatic-nanoparticles;    distinct ultraviolet–visible peaks;    shape-dependent nanoconjugates;    enhanced bactericidal activity;    azithromycin-coated silver nanoprisms;    spherical-shaped counterparts;    human beings;    microbial infections;    strategic alternate tools;    metallic nanomaterials;    bactericidal properties;    silver NM;    medical losses;    metallic NM;    Fourier transform infrared spectroscopy;    Escherichia coli;    Staphylococcus aureus;    Ag;   

DOI  :  10.1049/mnl.2019.0704

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Human beings have been bearing great medical, social, and economic losses due to the ever-increasing rate of microbial infections and the development of resistance; hence, there is a dire need to develop novel strategic alternate tools to circumvent these infections. In this regard, metallic nanomaterials (NMs) have been reported to exhibit promising bactericidal properties. In the present study, two different shaped silver NMs, i.e. silver nanoparticles (AgNPs) and silver nanoprisms (AgNPrs) and their conjugates with azithromycin were synthesised, characterised, and tested for their bactericidal activity. The average particle sizes analysed for spherical nanoparticles were 30–47.5 nm, and for prismatic-nanoparticles was 35–60 nm, respectively. The distinct ultraviolet–visible peaks were obtained for NMs and their nanoconjugates. The results of Fourier transform infrared spectroscopy indicated the interaction of various functional groups from Azy with metallic NMs. The nanoprisms and their conjugates showed enhanced bactericidal potential as compared to AgNPs and their corresponding control. The efficiency of Azy–AgNPrs was statistically higher ( P <0.05) than AgNPs, Azy–AgNPs, and AgNPrs against the growth of Escherichia coli and Staphylococcus aureus . These results can be used as an innovative tool for further in-depth optimisation of shape-dependent nanoconjugates for their bactericidal activity.

【 授权许可】

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