Influence of tilting effect on charge structure and lightning flash density in two different convective environments

Meteorological applications

article

Maryam Gharaylou¹  Nafiseh Pegahfar²  Majid M. Farahani¹ 

[1] Institute of Geophysics, University of Tehran;Atmospheric Sciences Research Center, Iranian National Institute for Oceanography and Atmospheric Science

关键词: Newborn;    Jaundice;    Phototherapy;    Clofibrate;    Serum Bilirubin;    Icterus;    Randomized-Controlled Trial"/>;   

DOI  :  10.1002/met.1957

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Objectives: To compare the effects of a single dose of clofibrate on the serum bilirubin level in full-term non-hemolytic icteric neonates when it is administered in addition to phototherapy, and to evaluate its possible side effects. Methods: In a randomized-controlled clinical trial in 2016, 90 term icteric neonates were divided into groups of 30. One group took a single dose of 50 mg/kg while another group took a single dose of 100 mg/kg of clofibrate. All neonates were under phototherapy and were compared to a control group who took a placebo. Serum bilirubin levels were measured at admission and then after 6, 12, 24, and 48 hours of treatment. Clofibrate’s side effects were assessed by measuring hepatic enzymes (AST/ALT) and lipid profiles (TG/Chol) at admission and after 48 hours. Results: In neonates with jaundice who were under phototherapy, a single dose of 100 mg/kg of clofibrate decreased the level of serum bilirubin more rapidly compared to the control group ( t (58) = -2.73, P = 0.043), or even the group who took a single dose of 50 mg/kg clofibrate ( t (58) = -4.261, P = 0.000). A single dose of 50 mg/kg clofibrate did not decrease the serum bilirubin levels more rapidly compared to the control group. Compared to the control group, in the group who took a single dose of 50 mg/kg clofibrate, after 48 hours, a higher number of neonates showed an increase in serum triglyceride (30% versus 63%) and/or cholesterol levels (27% versus 57%). Conclusions: A single dose of 100 (not 50) mg/kg clofibrate better decreased the serum bilirubin.

【 授权许可】

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