Transcription factor 4 expression in circulating tumor cells from castration-resistant prostate cancer

IJU Case Reports

article

Naoya Nagaya¹  Geun Taek Lee²  Yan Lu¹  Takeshi Ashizawa¹  Masayoshi Nagata¹  Isaac Yi Kim²  Shigeo Horie¹ 

[1] Department of Urology, Juntendo University Graduate School of Medicine;Section of Urologic Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School

关键词: androgen receptor;    castration-resistant prostate cancer;    circulating tumor cells;    neuroendocrine differentiation;    transcription factor 4;   

DOI  :  10.1002/iju5.12272

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Introduction Neuroendocrine differentiation is partly caused by antiandrogen therapy and exhibits an androgen receptor-independent growth mechanism. We hypothesized that the expression of transcription factor 4, an inducer of neuroendocrine differentiation, in circulating tumor cells is related to drug resistance in castration-resistant prostate cancer. Case presentation We evaluate the messenger ribonucleic acid expression of transcription factor 4 in circulating tumor cells from 17 patients with castration-resistant prostate cancer and compared these levels between patients receiving antiandrogen therapies and those who were resistant to antiandrogen therapies and receiving chemotherapies. The expression of transcription factor 4 in circulating tumor cells was significantly higher among patients receiving chemotherapies. Conclusion This study shows that transcription factor 4 is higher in the group of patients who were judged by their physicians to need chemotherapy treatment.

【 授权许可】

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