Nonmetastatic castration-resistant prostate cancer treated with salvage focal brachytherapy after external beam radiotherapy

IJU Case Reports

article

Soichiro Yoshida¹  Yoh Matsuoka¹  Kazuma Toda¹  Sho Uehara¹  Hajime Tanaka¹  Minato Yokoyama¹  Kazutaka Saito¹  Ryoichi Yoshimura¹  Yasuhisa Fujii¹ 

[1] Department of, Tokyo Medical and Dental University

关键词: brachytherapy;    hemi-gland focal therapy;    prostatic neoplasms;    castration-resistant;    radiotherapy;    salvage therapy;   

DOI  :  10.1002/iju5.12294

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Introduction The efficacy of salvage local therapy after external beam radiotherapy has recently gained attention. However, a challenge with these therapies is the risk of significant genitourinary and gastrointestinal toxicity. Focal brachytherapy may be a treatment option because of its potential to reduce side effects. Case presentation A patient with castration-resistant prostate cancer was found to be free of metastases on whole-body magnetic resonance imaging following external beam radiotherapy, and prostate biopsy revealed a localized recurrence in the ventral prostate. The patient underwent salvage focal brachytherapy and had a prostate-specific antigen progression-free survival of 23 months. No adverse effects were observed following salvage brachytherapy. Conclusion Our case suggests that salvage focal brachytherapy may be an effective local treatment option for nonmetastatic castration-resistant prostate cancer that has relapsed after external beam radiotherapy, wherein the lesion is confined to a small area within the prostate.

【 授权许可】

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