Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial

Reproductive medicine and biology

article

Quoc Huy Hoang¹  Hung Sy Ho²  Huong Thuy Do⁴  Tien Viet Nguyen²  Hong Phuong Nguyen⁵  Minh Tam Le⁷ 

[1] Department of Obstetrics and Gynecology, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen University;Department of Obstetrics and Gynecology, Hanoi Medical University;National Assisted Reproductive Technology Centre, National Hospital of Obstetrics and Gynecology;Department of Histology and Embryology, Hanoi Medical University;Department for Science Technology and International Cooperation, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen University;International Food Policy Research Institute;Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University;Hue Center for Reproductive Endocrinology and Infertility, Hue University Hospital

关键词: controlled ovarian hyperstimulation;    in vitro fertilization;    infertility;    poor ovarian response;    testosterone;   

DOI  :  10.1002/rmb2.12383

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods In this randomized control trial, infertile women with POR who underwent in vitro fertilization (IVF) were recruited and randomly classified into 4 week (n = 42) and 6 week (n = 38) TTG treatment groups and control group (n = 42). The primary outcome was total number of retrieved mature oocytes. The secondary outcomes were the biochemical pregnancy rate, clinical pregnancy rate, and ongoing pregnancy rate. Results No significant differences were observed in the number of oocytes retrieved, mature oocytes and embryos between all groups. Human chorionic gonadotropin (hCG) positive, clinical, and ongoing pregnancy rates were significantly higher in the TTG pretreatment groups than in the control group but no differences were observed between the 4- and 6 week groups. Conclusions Applying TTG in infertile women with POR may ameliorate the outcomes of IVF. The extended application of TTG to 6 weeks did not improve the response to ovarian stimulation regarding the number of retrieved oocytes nor pregnancy outcomes compared to the 4 week pretreatment.

【 授权许可】

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