Testicular teratoma demanded in-depth pathological exploration to rule out malignancy: A pediatric case report

IJU Case Reports

article

Yoshinobu Moritoki¹  Kentaro Mizuno³  Taiki Kato¹  Shuzo Hamamoto¹  Hideo Hattori⁴  Yasuhiko Ito⁵  Shinji Saitoh⁵  Takahiro Yasui¹  Yutaro Hayashi³ 

[1] Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences;Department of Urology, Anjo Kosei Hospital;Department of Pediatric Urology, Nagoya City University Graduate School of Medical Sciences;Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences;Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences

关键词: alpha-fetoprotein;    testicular teratoma;    yolk sac tumor.;   

DOI  :  10.1002/iju5.12050

学科分类：社会科学、人文和艺术（综合）

来源: Wiley

【 摘 要 】

Introduction Prepubertal testicular tumors can be both benign and malignant. Although most testicular teratomas are benign, some immature cases include malignant transformation or the mixed type with yolk sac tumor and, occasionally, it is challenging to rule out malignancy. Case presentation We present a case of immature testicular teratoma in a 7-month-old infant, whose alpha-fetoprotein level was sequentially elevated following orchidectomy. Since malignancy could not be ruled out, we performed whole body imaging and in-depth pathological exploration. GLYPICAN3, OCT3/4, and SOX2 staining revealed no evidence of malignancy. The patient was finally diagnosed with benign immature teratoma, and has been free from recurrence for 3 years. Conclusion Here, we describe the case report, as well as all the comprehensive diagnostic tests that we performed in order to rule out the malignant component.

【 授权许可】

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