Recombinant follicle-stimulating hormone (follitropin alfa) for ovulation induction in Japanese patients with anti-estrogen-ineffective oligo- or anovulatory infertility: results of a phase II dose–response study

Reproductive medicine and biology

article

Yuji Taketani¹  Eduardo Kelly²  Yasunori Yoshimura³  Hiroshi Hoshiai⁴  Minoru Irahara⁵  Hideki Mizunuma⁶  Hidekazu Saito⁷  Kazumichi Andoh⁸  Zourab Bebia⁹  Takumi Yanaihara^1,10 

[1] Department of Obstetrics and Gynecology, Graduate School of Medicine, Faculty of Medicine, University of Tokyo;Inc.;Department of Obstetrics and Gynecology, School of Medicine, Keio University;Department of Obstetrics and Gynecology, School of Medicine, Kinki University;Department of Obstetrics and Gynecology, The University of Tokushima Faculty of Medicine;Department of Obstetrics and Gynecology, School of Medicine, Hirosaki University;Division of Reproductive Medicine, National Center for Child Health and Development;Department of Gynecology, Japanese Red Cross Medical Center;Merck Serono S.A.-Geneva;Department of Obstetrics and Gynecology, Showa University School of Medicine

关键词: Amenorrhea Chronic low-dose step-up regimen Follitropin alfa Ovulation induction Recombinant human follicle-stimulating hormone;   

DOI  :  10.1007/s12522-009-0044-7

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: Children with mental disability show below average intellectual abilities and social behavior adaptability. Living with a disabled child can have profound effects on the entire family–parents, siblings, and extended family members. Meeting the needs of children with disabilities can be challenging for schools and families. However, effective support for children’s mental health and wellbeing involves efforts to meet the social, emotional and learning needs of all children. This study aimed to investigate factors affecting the occurrence of mental disability in children aged 6 to 15 years old. Subjects and Method: This was an analytic observational study using case control design. The study was conducted in Ponorogo District, East Java, from March to April 2017. A sample of 150 children aged 6 to 15 years old, consisting of 50 children with mental disability and 100 children without mental disability, were selected for this study by fixed disease sampling. The exogenous variables were prematurity, maternal age during pregnancy, maternal stress during pregnancy, hereditary history, family income, parental education, and environmental exposure. The endogenous variables were maternal nutritional status, low birthweight, and mental disability. The data were collected by a questionnaire, and analyzed by path analysis. Results: Mental disability was directly affected by maternal age (b= 2.52, 95% CI = 1.23 to 3.81, p<0.001), low birthweight (b= 2.32, 95% CI = 1.11 to 3.54, p<0.001), hereditary history (b= 2.54, 95% CI = 1.34 to 3.74, p<0.001). Mental disability was indirectly affected by maternal nutritional status, maternal stress, maternal education, family income, and environmental exposure. Conclusion: Maternal age, low birthweight, and hereditary history, directly affect mental disability. Maternal nutritional status, maternal stress, maternal education, family income, and environmental exposure, indirectly affect mental disability.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND