A study of the effect of an extremely low oxygen concentration on the development of human embryos in assisted reproductive technology

Reproductive medicine and biology

article

Koji Nakagawa¹  Asako Shirai¹  Yayoi Nishi¹  Rie Sugiyama¹  Yasushi Kuribayashi¹  Rikikazu Sugiyama¹  Masato Inoue¹ 

[1] Division of Reproductive Medicine, Sugiyama Clinic

关键词: ART Embryo development Embryo quality High oxygen Low oxygen;   

DOI  :  10.1007/s12522-010-0052-7

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: Monitoring child development is an important step to prepare healthy children from the earliest age, both physically, spiritually, and socially. Monitoring child development can be done in the kindergarten. Some kindergartens in Surakarta, however, have not implemented child development monitoring program. This study aims to determine the effect of prematurity, birthweight, maternal stress, socio-economic status, and mother-child intimacy, on the development of preschool children. Subje cts and Met ho d : This was an analytical observational study using case control design. The study was carried out at 7 kindergartens (TK) in Surakarta, Central Java: TK Negeri Pembina, TK Gaya Baru III, TK Kristen Ngasinan, TK Islam Bakti 6, TK Advent, TK Warga and TK Kanisius Imakulata, from May to June 2017. A sample of 120 children aged 5-6 years old attending kindergartens were selected for this study by fixed exposure sampling, i.e. selection based on prematurity status. The dependent variable was child development. The independent variables were prematurity, birthweight, maternal stress, maternal employment status, maternal education, family income, parenting time, and mother-child intimacy. The data were collected by a set of pre-tested questionnaire. Child development was measured by development pre-screening questionnaire (KPSP). Nutritional status was obtained from maternal and child health recording book. Path analysis was employed for data analysis. Results : Child development was directly affected by prematurity (b=0.29; SE=0.07; p<0.001), birthweight (b=0.04; SE= 0.18; p=0.007), maternal employment (b=0.46; SE=0.20; p=0.020), maternal education (b=0.65; SE=0.21; p=0.002), family income (b=0.01; SE=0.01; p=0.015), and mother-child intimacy (b=0.26; SE=0.05; p<0.001). Family income was affected by maternal employment (b=23.37; SE=5.52; p<0.001) and maternal education (b=23.50; SE=5.79; p<0.001). Mother-child intimacy was affected by maternal stress (b=0.01; SE=0.01; p=0.052) and parenting time (b=0.56; SE=0.05; p<0.001). Conclusions: Child development is directly affected by prematurity, birthweight, maternal employment, maternal education, family income, and mother-child intimacy.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND