An immunohistochemical study of metroplastic surgical specimens from patients with a septate uterus

Reproductive medicine and biology

article

Tsunehisa Makino¹  Li-yi Cai¹  Shun-ichiro Izumi¹  Masanori Yasuda³ 

[1] Department of Obstetrics and Gynecology, School of Medicine, Tokai University;Tohbu Hospital;Department of Pathology, School of Medicine, Tokai University

关键词: Congenital uterine anomaly Immunohistochemistry Metroplasty Recurrent pregnancy loss Uterine vessel distribution;   

DOI  :  10.1007/s12522-011-0103-8

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: Various products are common in the market for v aginal hygiene purpose, such as povidone iodine vaginal douche, extract of betel leaf, and other herbal internal vaginal hygiene products. However, it is hypothesized that these hygiene products may hamper female fertility. This study aimed to examine t he effect of vaginal hygiene product use on female fertility, while controlling for the level of physical activity, age at marriage, and body mass index. Subjects and Method : This study was analytical-observational with case control design, conducted at Dr. Moewardi Hospital, Surakarta, Indonesia. The study population were women aged 15-49 years old. A total of 55 infertile women and 55 pregnant or post-partum women were selected as cases and controls, respectively, by using fixed diseases sampling. The dependent variable was infertility. The independent variables were external and internal use of vaginal hygiene product, level of physical activity, age at marriage, and body mass index (BMI). The data were analyzed using multiple logistic regression. Results : External use of vaginal hygiene product decreased the risk of infertility, but it was statistically non-significant (OR=0.62; 95%CI= 0.22 to 1.74; p =0.366) . Internal use of vaginal hygiene product (OR=14.97; 95%CI= 1.66 to 135.16; p =0.016), h eavy physical activity (OR=7.95; 95%CI= 1.54 to 41.08; p =0.013) , age at marriage>29 years (OR=3.66; 95%CI= 0.68 to 19.76; p =0.131) , BMI 29 years, underweight, and overweight, are risk factors of infertility in women. Women who use vaginal hygiene product internally should be aware that this practice significantly increased the risk of infertility.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND