Usefulness of statistics for establishing evidence-based reproductive medicine

Reproductive medicine and biology

article

Yasunori Sato¹  Masahiko Gosho³  Kiyotaka Toshimori⁴ 

[1] Clinical Research Center, Chiba University Hospital;Department of Biostatistics, Harvard School of Public Health;Department of Management Science, Graduate School of Engineering, Tokyo University of Science;Department of Anatomy and Developmental Biology, Chiba University Graduate School of Medicine

关键词: Biostatistical methods Confounding factor Evidence-based reproductive medicine Exploratory data analysis Pregnancy rate;   

DOI  :  10.1007/s12522-011-0106-5

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: Digestive tract disease is still a health problem around the world, currently there are 2,544,084 cases of diarrhea in Indonesia in 2016. In the Central Java region, there are an estimated of 911,901 cases of diarrhea, while 95,635 cases of diarrhea have been handled. This study aims to estimate the magnitude of the effect of probiotics on the frequency and duration of diarrhea among toddler based on the results of a number of similar previous studies. Subjects and Method: This study was a systematic study and meta-analysis, with PICO as follows: Population= children under five. Intervention= Probiotics. Comparison= Not Probiotic. Outcome= Frequency and Duration of Diarrhea in toddlers. The articles used in this study were obtained from several databases including PubMed, Springer Link, Cochrane Database, Hindawi, Elsevier, JBBA, LWW, Google Scholar. The keywords for search­ing articles are as follows: "Probiotic", OR "fre­quency", OR "diarrhea", "kid", OR child "AND" Randomized Controlled Trial (RCT). The articles included in this study were full text articles with a randomized controlled trial study design. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application. Results: A total of 12 articles reviewed in this meta-analysis study originated from India, Canada, Indonesia, America, Iran. Studies showed that the effect of probiotics decreased the frequency (Standarized mean difference -0.32; 95% CI= -0.67 to 0.03 p= 0.070). The effect of probiotics reduced the duration of diarrhea in children under five (Standarized mean diffe­rence= -0.74; 95% CI= -1.60 to 0.12 p= 0.090). Conclusion: Probiotics reduced the frequency and duration of diarrhea in toddlers.

【 授权许可】

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