Alterations of the ovarian histomorphometry at pre-puberty in rat offspring from diabetic mothers

Reproductive medicine and biology

article

Zabihollah Khaksar¹  Gholamali Jelodar¹  Hooman Hematian²  Mohamad Poorahmadi³ 

[1] Department of Basic Sciences, School of Veterinary Medicine, Shiraz University;Department of Veterinary Sciences, Yasooj Branch, Islamic Azad University;Department of Basic Sciences, Jahrom Medical University

关键词: Follicle Maternal diabetes Offspring Ovary Rat;   

DOI  :  10.1007/s12522-013-0151-3

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: Breast cancer is the most common type of cancer suffered by women in the world. The combination of tamoxifen and chemotherapy significantly reduces the risk of recur­rence and mortality in breast cancer patients. This study aimed to analyze how effective the com­bination of tamoxifen and chemotherapy after surgery to reduce the risk of recurrence and mortality in breast cancer patients with positive hormone receptor. Subjects and Method: This study used systematic review and meta-analysis. The researcher collected articles from the Pubmed journal database. The subjects of the study were women with breast cancer after surgery. The dependent variable was recurrence and survival (mortality). The independent variables were tamoxifen and chemotherapy. Data were analyzed based on the fixed and random effects model using RevMan 5 software. Results: There were 3 articles with 3,761 women who were involved in the analysis process. The combination of tamoxifen and chemotherapy could reduce the risk of recurrence in women with positive hormone receptor (ER+) breast cancer (HR=0.68; 95%CI=0.58 to 0.80; p=0.001). The combination of tamoxifen and chemotherapy showed weak and non-significant decreasing trend in reducing the risk of mortality in women with ER+breast cancer (HR=0.87; 95%CI=0.73 to 1.03; p= 0.11). Conclusion: The combination of tamoxifen and chemotherapy in women with ER+ breast cancer is effective in reducing the risk of recurrence. However, it does not increase survival.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND