Effect of single-oocyte culture system on in vitro maturation and developmental competence in mice

Reproductive medicine and biology

article

Manami Nishio¹  Yumi Hoshino¹  Kentaro Tanemura¹  Eimei Sato¹ 

[1] Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University

关键词: Hanging drop In vitro maturation Mouse oocyte Oocyte quality Single culture;   

DOI  :  10.1007/s12522-014-0177-1

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: The maintenance phase in methadone maintenance therapy required a long time un­til the patient was declared recovered, so that it often caused saturation and results in high drop­out rates. Therapy retention or survival of patients in the process of therapy was one indicator of the success of this methadone therapy. This study aims to determine the effect of patient charac­te­ris­tics and methadone maintenance therapy dose on the retention of methadone therapy at H. Adam Malik General Hospital Medan. Subjects and Method: This study used a cross sectional design and was carried out at H. Adam Malik General Hospital in Medan. The number of samples in this study was the total population of 63 patients in the maintenance phase January 2017 to January 2018. The dependent variable was the retention of methadone therapy and the independent variables included age, education level, ma­rital status, work status, domicile, and average maintenance dose even. The data in this study were obtained from the medical record data of maintenance phase methadone patients and the data analysis was done using multiple logistic regression tests. Results: The results showed that the average maintenance dose had an effect on retention of me­tha­done therapy (OR = 5.94, 95% CI 1.06 to 33.18, p = 0.042). Conclusions: The maintenance dose of ≥60 mg affects the retention of methadone therapy 6 times higher than the dose of <60 mg.

【 授权许可】

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