Changes in expression levels of oxidative stress-related genes in mouse epididymides by neonatal exposure to low-dose decabromodiphenyl ether

Reproductive medicine and biology

article

Makoto Nakamoto¹  Hidenobu Miyaso¹  Masatoshi Komiyama²  Yoshiharu Matsuno¹  Chisato Mori¹ 

[1] Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University;Department of Physiology and Biochemistry, Graduate School of Nursing, Chiba University;Center for Preventive Medical Science, Chiba University

关键词: Decabromodiphenyl ether (decaBDE) Diethylstilbestrol (DES) Alterations in gene expression on epididymis Oxidative stress Thyroid hormone;   

DOI  :  10.1007/s12522-013-0173-x

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background : Chronic kidney disease (CKD) is a major cause of changes in activity, psychology and life. Analysis of the use of hemodialysis on quality of life was carried out as a treatment eva­lu­a­tion to maintain the survival of CKD patients. This study aimed to determine the determinants qu­a­­lity of life among he­modialysis patients. Subjects and Method : This was a cross-sectional study conducted at the Hospital Hemodialysis Unit Dr. Hardjono, Ponorogo, East Java, in April 2019. A total sample of 200 hemodialysis patients we­­re selected using simple random sampling. The dependent variable was the quality of life of he­mo­­dialysis patients. The independent variables were age, gender, education, type of financing, fa­mi­ly­ income, stress, frequency of hemodialysis, level of physical dependence, comorbidity, and so­cial group. The data of life quality were collected using the Kidney Disease Quality of Life (KDQoL) SF-36 questionnaire and analyzed using multiple logistic regressions. Results : The quality of life of hemodialysis patients was affected by age ≥ 50 years (b = -1.40; CI 95% = -2.42 to -0.36; p = 0.008), severe stress (b = -1.73; CI 95% = -2.91 to -0.54; p = 0.004), had co­­­morbidity (b = -1.25; CI 95% = -2.29 to -0.23; p = 0.017), male sex (b = 1.48; CI 95% = 0.41 to 2.54; p = 0.007), education high (b = 1.46; 95% CI = 0.43 to 2.50; p = 0.006), family income ≥ mi­ni­­mum wage (b = 1.98; 95% CI = 0.75 to 3.20; p = 0.002), PBI financing type (b = 1.69; 95% CI = 0.40 to 2.98; p = 0.010), frequency of hemodialysis often (b = 1.21; 95% CI = 0.20 to 2.22; p = 0.019), independent physical dependence level (b = 1.41; 95% CI = 0.33 to 2.49 ; p = 0.011), and has a social group (b = 3.28; 95% CI = 1.12 to 9.65; p = 0.031). Conclusions : Age, gender, education, type of financing, family income, stress, frequency of he­mo­di­a­lysis, level of physical dependence, comorbidity, and social group affect the quality of life of he­mo­­dialysis patients.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND