Making the first decision: lessons from the mouse

Reproductive medicine and biology

article

Agnieszka Jedrusik¹ 

[1] Wellcome Trust/CR UK Gurdon Institute;Department of Physiology, Development and Neuroscience, University of Cambridge

关键词: Blastocyst Compaction ICM Polarization Trophectoderm;   

DOI  :  10.1007/s12522-015-0206-8

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Pre-implantation development encompasses a period of 3–4 days over which the mammalian embryo has to make its first decision: to separate the pluripotent inner cell mass (ICM) from the extra-embryonic epithelial tissue, the trophectoderm (TE). The ICM gives rise to tissues mainly building the body of the future organism, while the TE contributes to the extra-embryonic tissues that support embryo development after implantation. This review provides an overview of the cellular and molecular mechanisms that control the critical aspects of this first decision, and highlights the role of critical events, namely zytotic genome activation, compaction, polarization, asymmetric cell divisions, formation of the blastocyst cavity and expression of key transcription factors.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND