Sperm dysfunction and ciliopathy

Reproductive medicine and biology

article

Kazuo Inaba¹  Katsutoshi Mizuno¹ 

[1] Shimoda Marine Research Center, University of Tsukuba;Department of Biological Sciences, Dartmouth College

关键词: Cilia Ciliopathy Dynein Flagella Sperm Infertility;   

DOI  :  10.1007/s12522-015-0225-5

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Sperm motility is driven by motile cytoskeletal elements in the tail, called axonemes. The structure of axonemes consists of 9 + 2 microtubules, molecular motors (dyneins), and their regulatory structures. Axonemes are well conserved in motile cilia and flagella through eukaryotic evolution. Deficiency in the axonemal structure causes defects in sperm motility, and often leads to male infertility. It has been known since the 1970s that, in some cases, male infertility is linked with other symptoms or diseases such as Kartagener syndrome. Given that these links are mostly caused by deficiencies in the common components of cilia and flagella, they are called “immotile cilia syndrome” or “primary ciliary dyskinesia,” or more recently, “ciliopathy,” which includes deficiencies in primary and sensory cilia. Here, we review the structure of the sperm flagellum and epithelial cilia in the human body, and discuss how male fertility is linked to ciliopathy.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND