Phase III trial of 8% vaginal progesterone gel for luteal phase support in Japanese women undergoing in vitro fertilization and fresh embryo transfer cycles

Reproductive medicine and biology

article

Shoji Kokeguchi¹  Naoki Hayashi²  Daniela Rogoff³  Shin Shimizu⁴  Osamu Ishihara⁵ 

[1] Hanabusa Women's Central Fertility Clinic;Muse Ladies Clinic;EMD Serono Research & Development Institute, Inc.;Merck Serono Company, Ltd;Saitama Medical University Hospital

关键词: assisted reproductive techniques;    embryo transfer;    in vitro fertilization;    luteal (phase) support;    progesterone;   

DOI  :  10.1002/rmb2.12009

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background : Physical exercise can improve antioxidant defense system of organis. But long and heavy exercise can disrupt the balance of oxidant-antioxidant. Low glutathione peroxidase is associated with free radicals. Plant purple sweet potatoes (Ipomoea batatas L.) contain anthocyanins high enough that act as antioxidants. This stu­dy aimed to determine the effect of extracts of tubers of purple sweet potato (Ipomoea Batatas L.) on the activity of glutathione peroxidase (GPx) liver of mice (Mus Musculus) treated with maximal physical exercise. Subjects and Method : This was a true experimental study. This conducted with the design of the control group post-test only in vivo on 24 white male mice (Mus musculus), DD Webster strain. Da­ta analysis was using SPSS software 19. Statistical testing decision taken 5% significance level (p=0.05). Results : The results showed that the average enzyme activity of GPx in the P5 is the highest enzyme activity GPx (mean=19:39 ± SD=7:06, p=0.024), which means there are significant differ­rences in the enzyme activity of GPx values between groups. Conclusion : This study showed that the extract could increase the activity of GPx hepatic enzyme­es mice significantly.

【 授权许可】

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