Molecular mechanism of estrogen–estrogen receptor signaling

Reproductive medicine and biology

article

Pelin Yaşar¹  Gamze Ayaz¹  Sırma Damla User¹  Gizem Güpür¹  Mesut Muyan¹ 

[1]Department of Biological Sciences, Middle East Technical University

关键词: estrogen;    estrogen receptor;    molecular mechanism;    signaling;    structure;   

DOI  :  10.1002/rmb2.12006

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background: The paradigm of medical education has been changed from Teacher Centered Learning (TCL) to Student Centered Learning (SCL) that implemented through Problem-Based Learning (PBL) method. Medical students are expected to have the ability to learn independently or known as self-directed learning (SDL). This tendency then measured by a scale known as the Self Directed Learning Readiness Scale (SDLRS). Perso­nality is one of the influential factors in this case. Extrovert personality type is considered mo­re suitable to the SDL method. This study aimed to determine differences in self-direct­ed learning readiness between introvert and extrovert personality type among medical stu­dents. Subject and Methods: This was an observational analytic study with cross sectional design. The subjects were medical students at Sebelas Maret University in 2010, 2011, 2012 and 2013. This used random sampling method. The subjects were categorized into ready and not ready for SDL. Type of personality was divided into introvert, ambivert and extrovert. Motivation was selected as a confounding variable and divided into high and low motivation. Data were analyzed using multivariate regression analysis. Results: There were 69 students included in this study. We found that 25(36.2%) students were introvert, 16 (23.2%) students were extrovert and 28 (40.6%) students were ambivert. Based on SDLR scores, 23 (33.3%) students were ready for SDL and 46 (66.7%) students were not. Logistic regression analysis showed that extrovert students had chance to be ready for SDL 0.70 fold lower than introvert students (OR = 0.70; 95% CI= 0.18 to 2.74; p= 0.604). Otherwise, ambivert students 0.83 fold lower than introvert students (OR = 0.83; 95%CI= 0.26 to 2.64; p = 0.745) to be ready for SDL. Conclusion: There was no statistically difference of SDLR between personality types.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND