Evaluation of transfer media containing different concentrations of hyaluronan for human in vitro fertilization

Reproductive medicine and biology

article

Takuji Nishihara¹  Yoshiharu Morimoto¹ 

[1] Division of Culture Environment, HORAC Grand Front Osaka Clinic

关键词: hyaluronan;    hyaluronic acid;    in vitro fertilization and embryo transfer;    transfer medium;   

DOI  :  10.1002/rmb2.12051

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose The aim of the present prospective study was to investigate the efficacy of hyaluronan (HA) using two different concentrations as embryo transfer media for in vitro fertilization embryo transfer cycles. Methods A total of 169 cycles undergoing fresh embryo transfer on day 2 or 3, 561 cycles undergoing frozen-thawed embryo transfer on day 2 or 3, and 484 cycles of frozen-thawed blastocyst transfer were included in this study. Patients were randomly divided into two groups: transferred with low (l-HA) or high (h-HA) concentrations of HA in transfer media. Results In the case of fresh embryo transfer cycles, no significant differences were observed in the pregnancy (l-HA 27.2%, h-HA 31.2%), implantation (l-HA 22.1%, h-HA 24.2%), or abortion (l-HA 24.0%, h-HA 20.8%) rates between the two groups. In the case of frozen-thawed embryo transfer cycles, no significant differences were noted in the pregnancy (l-HA 20.9%, h-HA 22.9%), implantation (l-HA 13.4%, h-HA 15.8%), or abortion (l-HA 17.2%, h-HA 21.5%) rates. In the case of frozen-thawed blastocyst transfer cycles, no significant differences were observed in the pregnancy (l-HA 46.0%, h-HA 41.8%), implantation (l-HA 45.8%, h-HA 41.3%), or abortion (l-HA 17.6%, h-HA 26.9%) rates. Conclusion The present results showed that pregnancy, implantation, and abortion rates with transfer media containing different HA concentrations were similar.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND