Generation of germ cells from pluripotent stem cells in mammals

Reproductive medicine and biology

article

Masafumi Hayashi¹  Takamasa Kawaguchi¹  Gabriela Durcova-Hills¹  Hiroshi Imai¹ 

[1] Laboratory of Reproductive Biology, Graduate School of Agriculture, Kyoto University;The Fukui Research Institute, Ono Pharmaceutical Companyy, Ltd.

关键词: embryonic stem cells;    germ line;    induced pluripotent stem cells;    primordial germ cells;    specification;   

DOI  :  10.1002/rmb2.12077

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC induction have been established in the mouse. Many attempts are reported to enhance our understanding of PGC development in other mammals, including human. Methods Here, original and review articles that have been published on PubMed are reviewed in order to give an overview of the literature that is focused on PGC development, including the specification of in vivo and in vitro in mice, human, porcine, and bovine. Results Mammalian PGC development, in vivo and in vitro, have been studied primarily by using the mouse model as a template to study PGC specification in other mammals, including human, porcine, and bovine. Conclusion The growing body of published works reveals similarities, as well as differences, in PGC establishment in and between mouse and human.

【 授权许可】

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