Identifying a possible factor for the increased newborn size in singleton pregnancies after assisted reproductive technology using cryopreserved embryos, in comparison with fresh embryos

Reproductive medicine and biology

article

Rena Ishii¹  Akiko Shoda¹  Michiyo Kubo¹  Satiko Okazaki¹  Minori Suzuki¹  Riho Okawa¹  Megumi Enomoto¹  Manami Shitanaka¹  Yoko Fujita¹  Kazuki Nakao¹  Nobutaka Shimada²  Michiharu Horikawa¹  Hiroaki Negishi¹  Yuji Taketani¹ 

[1] Women's Clinic Oizumi Gakuen;Artemis Women's Hospital

关键词: assisted reproductive technology;    birthweight;    endometrial preparation;    frozen embryo;    hormone replacement therapy;   

DOI  :  10.1002/rmb2.12206

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose To determine whether the cycle regimens that are used for endometrial preparation are associated with the birthweight (BW) after assisted reproductive technology (ART) using frozen-thawed embryo transfer (FET). Methods The BW of singletons who were born by ART using FET was compared retrospectively, according to whether a FET was conducted in a hormone replacement therapy cycle (HRT, n   = 403) or an ovulatory cycle (OVL, n = 117). The BW after timed intercourse (NAT, n = 162) also was investigated. Results There were no significant differences in the age of the mothers, percentage of primiparas, gestational periods, Body Mass Index, and sex ratio between the HRT and OVL cycles. The average BW from HRT was significantly greater than that of OVL. The BW from HRT was also greater, compared with NAT, while statistical significance was not achieved between OVL and NAT. The putative factors affecting the BW, such as ovarian stimulation protocols, endometrial thickness, and the stage and quality of embryos, could not explain the difference in the BW between the HRT and OVL cycles. Conclusion An increased BW from ART using FET seems to be ascribable to conditions of the endometrium, but not cryopreservation procedures per se, which might provide a mechanistic framework for understanding heavier neonates who are born by FET.

【 授权许可】

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