The microbiome and mosquito vectorial capacity: rich potential for discovery and translation

Microbiome

Kerri L. Coon¹  Serena Y. Zhao¹  Philip J. McCall²  Grant L. Hughes³  Cintia Cansado-Utrilla³ 

[1] Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA;Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK;Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Disease, Liverpool School of Tropical Medicine, Liverpool, UK;

关键词: Microbiome;    Vectorial capacity;    Density;    Competence;    Biting;    Extrinsic incubation period;    Longevity;    Mosquito;    Symbiosis;    Pathogen transmission;   

DOI  :  10.1186/s40168-021-01073-2

来源: Springer

【 摘 要 】

Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence, and the pathogen extrinsic incubation period all influence pathogen transmission. Recent studies also indicate that mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps regarding  mosquito–microbe interactions  that need to be addressed in order to exploit them efficiently. Here, we review current evidence of impacts of the microbiome on aspects of vectorial capacity, and we highlight likely opportunities for novel vector control strategies and areas where further studies are required.C7BhC7jCFhCSE5STu56XtaVideo abstract

【 授权许可】

CC BY