Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I

Journal of Neurodevelopmental Disorders

Jannath Begum-Ali¹  Isabel Quiroz¹  Emily J. H. Jones¹  Luke Mason¹  Mark H. Johnson²  Anna Kolesnik-Taylor³  Jonathan Green⁴  Shruti Garg⁴ 

[1] Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, WC1E 7HX, London, UK;Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, WC1E 7HX, London, UK;Department of Psychology, University of Cambridge, Cambridge, UK;Centre for Brain and Cognitive Development, Birkbeck, University of London, Henry Wellcome Building, Malet Street, WC1E 7HX, London, UK;Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK;Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK;

关键词: Neurofibromatosis type 1;    Auditory processing;    Habituation;    Change detection;    EEG;    Autism spectrum disorder;   

DOI  :  10.1186/s11689-021-09364-3

来源: Springer

【 摘 要 】

BackgroundSensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory processing differences requires observing atypical sensory reactivity prior to the emergence of other symptoms, which can be achieved through prospective studies.MethodsIn this longitudinal study, we examined auditory repetition suppression and change detection at 5 and 10 months in infants with and without Neurofibromatosis Type 1 (NF1), a condition associated with higher likelihood of developing ASD.ResultsIn typically developing infants, suppression to vowel repetition and enhanced responses to vowel/pitch change decreased with age over posterior regions, becoming more frontally specific; age-related change was diminished in the NF1 group. Whilst both groups detected changes in vowel and pitch, the NF1 group were largely slower to show a differentiated neural response. Auditory responses did not relate to later language, but were related to later ASD traits.ConclusionsThese findings represent the first demonstration of atypical brain responses to sounds in infants with NF1 and suggest they may relate to the likelihood of later ASD.

【 授权许可】

CC BY