Reference intervals for hemoglobin and mean corpuscular volume in an ethnically diverse community sample of Canadian children 2 to 36 months

BMC Pediatrics

Eshetu G. Atenafu¹  Mary Kathryn Bohn²  Khosrow Adeli²  Mohamed Abdelhaleem³  Jemila S. Hamid⁴  Cornelia M. Borkhoff⁵  Catherine S. Birken⁶  Jonathon L. Maguire⁷  Patricia C. Parkin⁸ 

[1] Biostatistics Department, Princess Margaret Cancer Center, University Health Network, Toronto, Canada;CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada;Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada;Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada;Haematopathology, Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada;Department of Mathematics and Statistics, University of Ottawa, Ottawa, Canada;Pediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada;Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada;Pediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada;Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada;Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;Pediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada;Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada;Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;Department of Pediatrics, and Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada;Pediatric Outcomes Research Team (PORT), Division of Pediatric Medicine and Sick Kids Research Institute, Hospital for Sick Children, Toronto, Canada;Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada;Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;The Hospital for Sick Children Research Institute, Peter Gilgan Centre for Research and Learning, 686 Bay St, M5G 0A4, Toronto, ON, Canada;

关键词: Reference intervals;    Hemoglobin;    Mean corpuscular volume;   

DOI  :  10.1186/s12887-021-02709-w

来源: Springer

【 摘 要 】

ObjectiveTo establish reference intervals for hemoglobin and mean corpuscular volume (MCV) in an ethnically diverse community sample of Canadian children 36 months and younger.MethodsWe collected blood samples from young children at scheduled primary care health supervision visits at 2 weeks, 2, 4, 6, 9, 12, 15, 18, 24, and 36 months of age. Samples were analyzed on the Sysmex XN-9000 Hematology Analyzer. We followed the Clinical and Laboratory Standards Institute guidelines in our analysis. Data were partitioned by sex and also combined. We considered large age partitions (3 and 6 months) as well as monthly partitions. Reference intervals (lower and upper limits) and 90% confidence intervals were calculated.ResultsData from 2106 children were included. The age range was 2 weeks to 36 months, 46% were female, 48% were European and 23% were of mixed ethnicity. For hemoglobin, from 2 to 36 months of age, we found a wide reference interval and the 90% confidence intervals indicated little difference across age groups or according to sex. For MCV, from 2 to 7 months of age there was considerable decrease in the reference interval, which was lowest during the second year of life, followed by a slight increase in the last months of the third year of life.ConclusionThese findings suggest adoption of a single hemoglobin reference interval for children 2–36 months of age. Further studies in children under 4 months of age are needed.Trial registrationTARGet Kids! cohort is registered at ClinicalTrials.gov. www.clinicaltrials.gov. Identifier: NCT01869530.

【 授权许可】

CC BY