A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro

Cell & Bioscience

Yuan-Chun Ma¹  Brian Hetrick²  Deemah Dabbagh²  Yuntao Wu²  Sijia He²  Ramin M. Hakami²  Adeyemi A. Olanrewaju²  Ghaliah Alluhaibi²  Linda D. Chilin²  Dongyang Yu³  Lewis A. Hofmann⁴ 

[1] Dr. Ma’s Laboratories Inc., V5J 0E5, Burnaby, BC, Canada;National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, 20110, Manassas, VA, USA;Virongy LLC, 20109, Manassas, VA, USA;World Health Science Organization, 20176, Leesburg, VA, USA;

关键词: SARS-CoV-2;    COVID-19;    Coronavirus;    Antiviral therapy;    Respiratory detox shot;    Traditional Chinese medicine;    SARS-CoV;    Influenza A;    Ha-CoV-2;    SARS-CoV-2 pseudovirus;   

DOI  :  10.1186/s13578-021-00609-1

来源: Springer

【 摘 要 】

BackgroundThe ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries and territories. Currently, there is no effective treatment for COVID-19 to reduce mortality. We investigated the potential anti-coronavirus activities from an oral liquid of traditional medicine, Respiratory Detox Shot (RDS), which contains mostly herbal ingredients traditionally used to manage lung diseases.ResultsHere we report that RDS inhibited the infection of target cells by lenti-SARS-CoV, lenti-SARS-CoV-2, and hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudoviruses, and by infectious SARS-CoV-2 and derived Ha-CoV-2 variants including B.1.1.7, B.1.351, P.1, B.1.429, B.1.2, B.1.494, B.1.1.207, B.1.258, and B.1.1.298. We further demonstrated that RDS directly inactivates the infectivity of SARS-CoV-2 virus particles. In addition, we found that RDS can also block the infection of target cells by Influenza A virus.ConclusionsThese results suggest that RDS may broadly inhibit the infection of respiratory viruses.

【 授权许可】

CC BY