Measuring the effectiveness of integrated vector management with targeted outdoor residual spraying and autodissemination devices on the incidence of dengue in urban Malaysia in the iDEM trial (intervention for Dengue Epidemiology in Malaysia): study protocol for a cluster randomized controlled trial

Trials

Frederic Schmitt¹  Frederic Baur¹  Tim Möhlmann²  Remco Suer²  Jason H. Richardson³  Neal Alexander⁴  Farah Diana Ariffin⁵  Nazni Wasi Ahmad⁵  Nurulhusna Ab Hamid⁵  Mitra Saadatian-Elahi⁶  Carole Langlois-Jacques⁷  Muriel Rabilloud⁷  Rose Nani Mudin⁸ 

[1] Bayer S.A.S, Environnemental Science, Crop Science Division, 16 rue Jean Marie Leclair, 69266, Lyon, Cedex 09, France;In2Care B.V., Marijkeweg 22, 6709PG, Wageningen, The Netherlands;Innovative Vector Control Consortium, Pembroke Place, L3 5QA, Liverpool, UK;MRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel St, WC1E 7HT, London, UK;Medical Entomology Unit, WHO Collaborating Centre for Vectors, Institute for Medical Research, Ministry of Health Malaysia, National Institutes of Health, Block C, Jalan Setia Murni U13/52, Seksyen U13, Setia Alam, 40170, Shah Alam, Malaysia;Service Hygiène, Epidémiologie, Infection, Vigilance et Prévention, Centre Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France;CIRI, Centre International de Recherche en Infectiologie, (Equipe Laboratoire des Pathogènes Emergents), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France;Université de Lyon, F-69000, Lyon, France; Université Lyon 1, F-69100, Villeurbanne, France; Hospices Civils de Lyon, Pôle Santé Publique, Service de Biostatistique et Bioinformatique, F-69003, Lyon, France; CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive, Équipe Biostatistique-Santé, F-69100, Villeurbanne, France;Vector Borne Disease Sector, Disease Control Division, Ministry of Health Malaysia, Level 4, Block E10, Complex E, Federal Government Administrative Center, 62590, Putrajaya, Malaysia;

关键词: Aedes;    Dengue;    Malaysia;    Epidemiology;    Cluster Randomized;    Vector control;    Autodissemination;    outdoor residual spray;   

DOI  :  10.1186/s13063-021-05298-2

来源: Springer

【 摘 要 】

BackgroundIn common with many South East Asian countries, Malaysia is endemic for dengue. Dengue control in Malaysia is currently based on reactive vector management within 24 h of a dengue case being reported. Preventive rather than reactive vector control approaches, with combined interventions, are expected to improve the cost-effectiveness of dengue control programs. The principal objective of this cluster randomized controlled trial is to quantify the effectiveness of a preventive integrated vector management (IVM) strategy on the incidence of dengue as compared to routine vector control efforts.MethodsThe trial is conducted in randomly allocated clusters of low- and medium-cost housing located in the Federal Territory of Kuala Lumpur and Putrajaya. The IVM approach combines: targeted outdoor residual spraying with K-Othrine Polyzone, deployment of mosquito traps as auto-dissemination devices, and community engagement activities. The trial includes 300 clusters randomly allocated in a 1:1 ratio. The clusters receive either the preventive IVM in addition to the routine vector control activities or the routine vector control activities only. Epidemiological data from monthly confirmed dengue cases during the study period will be obtained from the Vector Borne Disease Sector, Malaysian Ministry of Health e-Dengue surveillance system. Entomological surveillance data will be collected in 12 clusters randomly selected from each arm.To measure the effectiveness of the IVM approach on dengue incidence, a negative binomial regression model will be used to compare the incidence between control and intervention clusters. To quantify the effect of the interventions on the main entomological outcome, ovitrap index, a modified ordinary least squares regression model using a robust standard error estimator will be used.DiscussionConsidering the ongoing expansion of dengue burden in Malaysia, setting up proactive control strategies is critical. Despite some limitations of the trial such as the use of passive surveillance to identify cases, the results will be informative for a better understanding of effectiveness of proactive IVM approach in the control of dengue. Evidence from this trial may help justify investment in preventive IVM approaches as preferred to reactive case management strategies.Trial registrationISRCTN ISRCTN81915073. Retrospectively registered on 17 April 2020.

【 授权许可】

CC BY