Impact of erenumab on acute medication usage and health care resource utilization among migraine patients: a US claims database study

The Journal of Headache and Pain

Stewart J. Tepper¹  Lujia Zhou²  Ying Shen²  Pamela Vo³  Matias Ferraris³  Juanzhi Fang⁴  Mrudula Glassberg⁴  Ahmad Abdrabboh⁴ 

[1] Geisel School of Medicine at Dartmouth, Hanover, NH, USA;KMK Consulting Inc., Morristown, NJ, USA;Novartis Pharma AG, CH-4002, Basel, Switzerland;Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA;

关键词: Burden;    Efficacy;    Erenumab;    Health care resource utilization;    Migraine;    Preventive therapies;    Real-world evidence;   

DOI  :  10.1186/s10194-021-01238-2

来源: Springer

【 摘 要 】

BackgroundMigraine is one of the leading causes of disability worldwide. Erenumab is a fully human monoclonal antibody that targets the calcitonin gene-related peptide (CGRP) receptor. This study aimed to evaluate real-world evidence on the impact of erenumab on acute medication usage and health care resource utilization (HCRU) among migraine patients.MethodsThis retrospective effectiveness study utilized the US Optum’s de-identified Clinformatics® Data Mart database to identify migraine patients initiating erenumab between May 1, 2018 and September 30, 2019. Patients had to be at least 18 years old, with a minimum of three doses for erenumab in the 6-month post-index period and continuous medical/pharmacy coverage in the 12-month pre- and 6-month post-index period. The date of the first claim for erenumab served as the index date. Use of acute medications overall and at different drug class level, and HCRU were compared during the 6-month pre- vs. post-index period. Impact of erenumab on a composite endpoint of three possible events: 1) outpatient visit with a diagnosis of migraine and an associated acute medication claim within 7 days of the visit, 2) hospital admission with a primary diagnosis for migraine, or 3) emergency room visit with a primary diagnosis for migraine (any events that occurred ≤3 days apart were counted only once) was also evaluated.ResultsThe analysis included 3171 identified patients. At 6 months, following initiation of erenumab, acute medication use including the number of types of acute medication, number of claims of each medication and % of patients who received acute medication, and HCRU were significantly decreased. For the composite outcome, the mean number of events decreased from 1.03 to 0.77 (rate ratio: 0.75; 95% CI: 0.71 to 0.79; P < 0.0001). A decrease in the proportion of patients with any of the three events was also observed (52.7% vs. 39.5%, P < 0.0001).ConclusionIn this retrospective analysis, erenumab was associated with significantly reduced acute medication use and HCRU in a real-world setting, hence significantly reducing the burden of the disease. A composite endpoint could be used as a proxy to evaluate the burden of migraine attacks; however, further research is needed.

【 授权许可】

CC BY