Adverse reaction to Coartem (artemether/lumefantrine) resulting in oculogyric crisis

Maxillofacial Plastic and Reconstructive Surgery

Buyanbileg Sodnom-Ish¹  Emmanuel Kofi Amponsah²  Aaron Sowah Anyetei-Anum²  Paul Frimpong²  Soung Min Kim³ 

[1] Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Korea;Oral and Maxillofacial Microvascular Reconstruction LAB, Ghana Health Service, Brong Ahafo Regional Hospital, P.O. Box 27, Sunyani, Brong Ahafo, Ghana;Oral and Maxillofacial Microvascular Reconstruction LAB, Ghana Health Service, Brong Ahafo Regional Hospital, P.O. Box 27, Sunyani, Brong Ahafo, Ghana;Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Korea;

关键词: Antimalarial;    Artemether-lumefantrine;    Rapid diagnostic test;    Oculogyric crisis;    Dystonic reactions;   

DOI  :  10.1186/s40902-021-00300-y

来源: Springer

【 摘 要 】

BackgroundArtemether/lumefantrine (AL), sold under the brand name Coartem, is the most common artemisinin-based combination therapy for the treatment of malaria. Drug-induced oculogyric crisis is a neurological disorder characterized by frequent upward deviations of the eye. In the literature, no cases of Coartem-induced oculogyric crisis have been reported in Ghana.Case presentationA 19-year-old male patient, who presented fever measuring 37.9 °C, general body pains, and weakness was prescribed with antimalarial therapy artemether/lumefantrine, Coartem®, from a local pharmacy. Just after initiation of treatment, the patient complained of double vision, involuntary upward eye deviation, and inability to close both eyes. The patient was diagnosed with Coartem-induced oculogyric crisis and was treated with the cessation of the causing agent and intramuscular injection of promethazine hydrochloride.ConclusionsWhen a patient exhibits a neurological disorder, such as oculogyric crisis, with normal conscious state and normal vital signs, special attention should be given to obtaining a history of recently administered medications. Clinicians should recognize adverse reactions to drugs based on a thorough patient history and examination. The goal of this report was to present Coartem-induced oculogyric crisis.

【 授权许可】

CC BY