High-risk lesions of the breast: concurrent diagnostic tools and management recommendations

Insights into Imaging

Carmelo Sofia¹  Giorgio Ascenti¹  Francesca Catanzariti¹  Giuseppe Cicero¹  Maria Adele Marino¹  Daly Avendano²  Margarita Garza-Montemayor²  Katja Pinker-Domenig³  Emmanuele Venanzi Rullo⁴ 

[1] Department of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina, Italy;Department of Breast Imaging, Breast Cancer Center TecSalud, ITESM Monterrey, Nuevo Leon, Mexico;Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, Suite 705, 300 E 66th Street, 10065, New York, NY, USA;Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria;Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98124, Messina, Italy;

关键词: High-risk lesions;    Ultrasound;    Mammography;    B3 lesions;    Breast imaging;   

DOI  :  10.1186/s13244-021-01005-6

来源: Springer

【 摘 要 】

Breast lesions with uncertain malignant behavior, also known as high-risk or B3 lesions, are composed of a variety of pathologies with differing risks of associated malignancy. While open excision was previously preferred to manage all high-risk lesions, tailored management has been increasingly favored to reduce overtreatment and spare patients from unnecessary anxiety or high healthcare costs associated with surgical excision. The purpose of this work is to provide the reader with an accurate overview focused on the main high-risk lesions of the breast: atypical intraductal epithelial proliferation (atypical ductal hyperplasia), lobular neoplasia (including the subcategories lobular carcinoma in situ and atypical lobular hyperplasia), flat epithelial atypia, radial scar and papillary lesions, and phyllodes tumor. Beyond merely presenting the radiological aspects of these lesions and the recent literature, information about their potential upgrade rates is discussed in order to provide a useful guide for appropriate clinical management while avoiding the risks of unnecessary surgical intervention (overtreatment).

【 授权许可】

CC BY