Effectiveness of a digital alcohol moderation intervention as an add-on to depression treatment for young adults: study protocol of a multicentre pragmatic randomized controlled trial

BMC Psychiatry

Lisanne M. Koomen¹  Heleen Riper²  David D. Ebert³  Sjoerd L. A. Kosterman⁴  Tamara Q. de Bruijn⁵  Maria J. E. Schouten⁶  Jack J. M. Dekker⁶  Anna E. Goudriaan⁷  Matthijs Blankers⁸  Michael P. Schaub⁹ 

[1] Arkin BasisGGZ, Arkin Mental Health Care, Roetersstraat 210, Amsterdam, The Netherlands;Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands;Department of Research and Innovation, GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands;Amsterdam UMC, Vrije Universiteit Amsterdam, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands;Research Unit for Telepsychiatry and e-Mental Health, Department of Clinical Research, University of Southern Denmark, Odense, Denmark;Faculty of Medicine, University of Turku, Turku, Finland;Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands;Department of Outpatient Treatment of Common Mental Health Disorders, PuntP, Arkin Mental Health Care, Amsterdam, The Netherlands;Department of Prevention, Jellinek, Arkin Mental Health Care, Amsterdam, The Netherlands;Department of Research, Arkin Mental Health Care, Amsterdam, The Netherlands;Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands;Department of Research, Arkin Mental Health Care, Amsterdam, The Netherlands;Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Addiction Research and Amsterdam Public Health Research Institute, Amsterdam, The Netherlands;Department of Research, Arkin Mental Health Care, Amsterdam, The Netherlands;Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Addiction Research and Amsterdam Public Health Research Institute, Amsterdam, The Netherlands;Trimbos Institute–The Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands;Swiss Research Institute for Public Health and Addiction, University of Zurich, Zurich, Switzerland;

关键词: Randomized controlled trial;    Depressive disorders;    Problematic alcohol use;    Digital intervention;    Comorbidity;    Young adults;    Depression treatment;    Effectiveness;    Cost-effectiveness;    Ehealth;   

DOI  :  10.1186/s12888-021-03222-1

来源: Springer

【 摘 要 】

BackgroundDepressive disorders and problematic drinking often co-occur, also among young adults. These co-occurring conditions are associated with various negative health outcomes compared to both conditions alone. Early intervention by addressing alcohol use and depressive symptoms simultaneously in the same treatment might improve both conditions. However, evidence on the (cost-) effectiveness of digital combined depression and alcohol interventions for young adults is currently insufficient. We therefore developed an add-on digital alcohol moderation adherence-focussed guided intervention to complement treatment as usual (TAU) for depressive disorders. The digital intervention is a web-app, including 6 modules based on motivational interviewing and cognitive behavioural therapy. This study aims to evaluate the (cost-)effectiveness of a digital alcohol moderation intervention + TAU compared to TAU on alcohol and depression outcomes among young adults with co-occurring depressive disorders and problematic alcohol use.MethodsOne hundred fifty-six participants, aged 18–35 years, with problematic alcohol use and a diagnosed depressive disorder will participate in a pragmatic multicentre two-arm randomized controlled trial. Problematic alcohol use is operationalised as scoring ≥5 for women and ≥ 8 for men on the Alcohol Use Disorder Identification Test (AUDIT). Participants will be randomized to either the experimental group (digital alcohol intervention + TAU) or control group (TAU only). Participants will be recruited at three Dutch mental health care centres and through social media. Assessments take place at baseline and after 3, 6 and 12 months post-randomization. The primary outcome is treatment response at 6-month follow-up, operationalized as a composite score that combines alcohol use and depression measures and indicates whether treatment has been successful or not. Secondary outcomes are depressive symptoms and alcohol use (i.e. number of weekly standard drinks and AUDIT score). An economic evaluation will be conducted alongside the trial.DiscussionThis study evaluates the (cost-) effectiveness of an add-on digital alcohol moderation intervention for young adults who are in treatment for depressive disorders. If proven effective, the digital intervention could be implemented in mental health care and improve treatment for people with co-occurring depressive disorders and problematic alcohol use.Trial registrationPre-registered on October 29, 2019 in The Netherlands Trial Register (NL8122).

【 授权许可】

CC BY