Clinical characteristics and factors related to antibiotic-associated diarrhea in elderly patients with pneumonia: a retrospective cohort study

BMC Geriatrics

Takeshi Morimoto¹  Noriko Fukiwake²  Toshihiro Imada²  Yoko Takedani²  Junji Mashino³  Tsukasa Nakamura⁴ 

[1] Clinical Education and Research Center, Shimane Prefectural Central Hospital, Izumo, Japan;Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, 663-8501, Nishinomiya, Hyogo, Japan;Department of General Medicine, Shimane Prefectural Central Hospital, Izumo, Japan;Department of General Medicine, Shimane Prefectural Central Hospital, Izumo, Japan;Clinical Education and Research Center, Shimane Prefectural Central Hospital, Izumo, Japan;Department of Infectious Diseases, Shimane Prefectural Central Hospital, Izumo, Japan;Clinical Education and Research Center, Shimane Prefectural Central Hospital, Izumo, Japan;

关键词: Antibiotic-Associated Diarrhea (AAD);    β-Lactamase Inhibitor;    Proton Pump Inhibitor (PPI);   

DOI  :  10.1186/s12877-021-02267-x

来源: Springer

【 摘 要 】

comorbidities, vital signs, laboratories, the severity of pneumonia, antibiotic and other medication use.ResultsThere were 1,067 patients, the mean age was 83 years, and men accounted for 59 %. β-Lactamase inhibitors were frequently prescribed antibiotics in 703 patients (66 %), and proton pump inhibitors (PPIs) were also commonly administered (48 %). AAD developed in 322 patients (30 %). The multivariate logistic regression model showed that β-lactamase inhibitors (OR 1.43, 95 % CI 1.05–1.95) and PPIs (OR 1.37, 95 % CI 1.03–1.83) were associated with AAD as well as age (OR 1.03 per year, 95 % CI 1.01–1.05).ConclusionsAAD was common among elderly inpatients with pneumonia, and β-lactamase inhibitors and PPIs were associated with AAD. Strict use of such medication should be considered to decrease the risk of AAD.

【 授权许可】

CC BY