Gene expression-based immune infiltration analyses of renal cancer and their associations with survival outcome

BMC Cancer

Kun Ma¹  Xiangyang Liu¹  Zilong Qi¹  Xinning Wang¹  Lei Chen¹  Liang Yin¹  Jinmin Li¹ 

[1] Department of Pediatric Surgery, Cangzhou Central Hospital, No.16 Xinhua West Road, 061000, Cangzhou, Hebei, China;

关键词: Renal cancer;    Tumor-infiltrating immune cells;    Proportion;    Prognosis;   

DOI  :  10.1186/s12885-021-08244-2

来源: Springer

【 摘 要 】

BackgroundRenal cancer is a common malignant tumor with an increasing incidence rate.MethodsIn this study, based on the gene expression profiles, we analyzed the compositions of tumor-infiltrating immune cells (TIICs) in renal cancer and paracancerous samples using CIBERSORT. The proportions of 22 TIICs subsets in 122 paired renal carcinoma and paracancerous samples, and 224 Wilms tumor (WT) samples varied between intragroup and intergroup.ResultsAfter analyzed the difference of TIICs composition between renal cancer and paired paracancerous samples, we found that M0 macrophages and CD8 T cells were significantly elevated, while naive B cells were significantly decreased in renal cancer samples compared with paracancerous samples. Survival analysis showed that high overall TIICs proportion, the low proportion of resting mast cells and the high proportion of activated memory CD4 T cells were associated with poor prognosis of renal cancer patients. In addition, 3 clusters were identified by hierarchical clustering analysis, and they presented a distinct prognosis. Cluster 1 had superior survival outcomes, while cluster 2 had an inferior survival outcome.ConclusionsOur study indicated that overall TIICs proportion, certain TIICs subset proportion, including resting mast cells and activated memory CD4 T cells, and distinct cluster patterns were associated with the prognosis of renal cancer, which was significant for the clinical surveillance and treatment of renal cancer.

【 授权许可】

CC BY