Large-cell neuroendocrine tumor of the prostate: a case report and review of the literature

Journal of Medical Case Reports

Jean-Charles Riffaud¹  Sarah Bleichner-Perez²  Sabine Assouad³  Jihen Kourda⁴  Mihaela Cosma-Opris⁴  Omar Karray⁵  Stéphane Bart⁵  Walid Sleiman⁵  Mikael Abi Abdallah⁵  Patrick Coloby⁵ 

[1] Centre de Radiothérapie et d’Oncologie Médicale de Pontoise, Osny, France;Nuclear Medicine Department, René Dubos Hospital, Pontoise, France;Oncology Department, René Dubos Hospital, Pontoise, France;Pathology Department, René Dubos Hospital, Pontoise, France;Urology Department, René Dubos Hospital, Pontoise, France;

关键词: Neuroendocrine carcinoma;    Prostate neoplasms;    Prostatectomy;    Local neoplasm recurrences;   

DOI  :  10.1186/s13256-021-02830-5

来源: Springer

【 摘 要 】

BackgroundPrimitive neuroendocrine prostate neoplasms are rarely reported. This entity comprises carcinoïd tumors and poorly differentiated neuroendocrine tumors, mainly those of the small-cell type. Large-cell-type primitive tumors are exceptional, and only nine cases are reported in the literature. Similar to neuroendocrine tumors of the prostate, large-cell-type primitive tumors may be observed in the context of conventional adenocarcinoma during androgen deprivation therapy or as prostatic metastasis of a distant neuroendocrine tumor, mainly pulmonary neoplasms.Case presentationWe report a Caucasian case of a mixed prostatic carcinoma, with the largest component being the large-cell neuroendocine carcinoma, in a patient who underwent a total prostatectomy for a localized cancer. Diagnostic, histological, therapeutic and evolutive aspects are reported and discussed.ConclusionsLarge-cell primitive prostate neuroendocrine carcinoma is a rare but aggressive histological entity, which can be associated or not with an adenocarcinomatous component. Mixed forms have a better outcome, mainly when diagnosed at an early stage.

【 授权许可】

CC BY