The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis

Antimicrobial Resistance & Infection Control

Alex van Belkum¹  Masoud Dadashi²  Bahareh Hajikhani³  Sana Amini³  Samira Zamani³  Hossein Goudarzi³  Mehdi Goudarzi³  Sareh Kakavandi³ 

[1] Data Analytics Unit, bioMérieux 3, Route de Port Michaud, La Balme Les Grottes, France;Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran;Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: Fusidic acid;    Staphylococcus aureus;    MRSA;    Meta-analysis;   

DOI  :  10.1186/s13756-021-00943-6

来源: Springer

【 摘 要 】

Background and aimStaphylococcus aureus (S. aureus) is one of the most common pathogens causing nosocomial and community-acquired infections with high morbidity and mortality rates. Fusidic acid has been increasingly used for the treatment of infections due to methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The present study aimed to determine the precise prevalence of fusidic acid resistant MRSA (FRMRSA), fusidic acid resistant MSSA (FRMSSA), and total fusidic acid resistant S. aureus (FRSA) on a global scale.MethodsSeveral international databases including Medline, Embase, and the Web of Sciences were searched (2000–2020) to discern studies addressing the prevalence of FRSA, FRMRSA, and FRMSSA. STATA (version14) software was used to interpret the data.ResultsOf the 1446 records identified from the databases, 215 studies fulfilled the eligibility criteria for the detection of FRSA (208 studies), FRMRSA (143 studies), and FRMSSA (71 studies). The analyses manifested that the global prevalence of FRSA, FRMRSA, and FRMSSA was 0.5%, 2.6% and 6.7%, respectively.ConclusionThis meta-analysis describes an increasing incidence of FRSA, FRMSSA, and FRMRSA. These results indicate the need for prudent prescription of fusidic acid to stop or diminish the incidence of fusidic acid resistance as well as the development of strategies for monitoring the efficacy of fusidic acid use.

【 授权许可】

CC BY