Determinants of bone health in elderly Japanese men: study design and key findings of the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) cohort study

Environmental Health and Preventive Medicine

Yuho Sato¹  Katsuyasu Kouda²  Kuniyasu Kamiya³  Koji Tsuda³  Junko Tamaki³  Jong-Seong Moon⁴  Masayuki Iki⁵  Akiko Yura⁵  Yuki Fujita⁵  Kumiko Ohara⁵  Jun Kitagawa⁶  Kazuki Kaji⁷  Takahiro Tachiki⁸  Masami Hamada⁸  Etsuko Kajita⁸ 

[1] Department of Human Life, Jin-ai University, 3-1-1 Ootemachi, Echizen, 915-8586, Fukui, Japan;Department of Hygiene and Public Health, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, 573-1010, Osaka, Japan;Department of Hygiene and Public Health, Osaka Medical and Pharmaceutical University, 2-7 Daigakumachi, Takatsuki, 569-8686, Osaka, Japan;Department of Nursing, Kio University, 4-2-2 Umami-naka, Koryo-cho, 635-0832, Nara, Japan;Department of Public Health, Kindai University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, 589-8511, Osaka, Japan;Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, 252-0373, Sagamihara, Kanagawa, Japan;Department of Rehabilitation, Kitasato University Kitasato Institute Hospital, Minato Ward, 5-9-1 Shirokane, Minato-ku, 108-8642, Tokyo, Japan;Faculty of Nursing, Chukyo Gakuin University, 2216 Tokicho, Mizunami, 509-6192, Gifu, Japan;

关键词: Bone mineral density;    Bone-multiorgan crosstalk;    Bone turnover marker;    Community-dwelling Japanese elderly men;    Death;    Fracture;    Osteoporosis;    Quality of life;    Risk model;   

DOI  :  10.1186/s12199-021-00972-y

来源: Springer

【 摘 要 】

BackgroundThe Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study was launched to investigate risk factors for osteoporotic fractures, interactions of osteoporosis with other non-communicable chronic diseases, and effects of fracture on QOL and mortality.MethodsFORMEN baseline study participants (in 2007 and 2008) included 2012 community-dwelling men (aged 65–93 years) in Nara prefecture, Japan. Clinical follow-up surveys were conducted 5 and 10 years after the baseline survey, and 1539 and 906 men completed them, respectively. Supplemental mail, telephone, and visit surveys were conducted with non-participants to obtain outcome information. Survival and fracture outcomes were determined for 2006 men, with 566 deaths identified and 1233 men remaining in the cohort at 10-year follow-up.CommentsThe baseline survey covered a wide range of bone health-related indices including bone mineral density, trabecular microarchitecture assessment, vertebral imaging for detecting vertebral fractures, and biochemical markers of bone turnover, as well as comprehensive geriatric assessment items. Follow-up surveys were conducted to obtain outcomes including osteoporotic fracture, cardiovascular diseases, initiation of long-term care, and mortality. A complete list of publications relating to the FORMEN study can be found at https://www.med.kindai.ac.jp/pubheal/FORMEN/Publications.html.

【 授权许可】

CC BY