Lithium carbonate as add-on therapy to radioiodine in the treatment on hyperthyroidism: a systematic review and meta-analysis

BMC Endocrine Disorders

Ahmed M. Afifi¹  Mohamed Sayed Zaazouee²  Mohamed Gadelkarim³  Omar Magdy Mohammed⁴  Mohamed Abdelmonem⁴  Ahmed Eissa Ahmed⁴  Mohamed Abd-ElGawad⁴  Ahmed Assar⁵ 

[1] Department of Internal Medicine and Division of Digestive Diseases, College of Medicine, University of Kentucky, Lexington, USA;Faculty of Medicine, Al-Azhar University, Assiut, Egypt;Faculty of Medicine, Alexandria University, Alexandria, Egypt;Faculty of Medicine, Fayoum University, 5 Al-Touba Street, from Al-Fanya Street, Al-Hadka road, Fayoum, Fayoum, Egypt;Faculty of Medicine, Menofia University, Shebin El-Kom, Menofia, Egypt;

关键词: Hyperthyroidism;    Lithium carbonate;    Radioactive iodine;    Cure rate;   

DOI  :  10.1186/s12902-021-00729-2

来源: Springer

【 摘 要 】

BackgroundThe main purpose is to investigate the effect of LiCO3 as an add-on therapy with radioactive iodine in increasing the cure and decreasing the T4 level compared to radioactive iodine alone. The primary outcome is the cure rate as defined by the number of hyperthyroid patients who became euthyroid or hypothyroid. The secondary outcome is the T4 level.MethodsFour databases were searched (PubMed, Scopus, Web of Science, and Cochrane central library). The inclusion criteria were randomized and non-randomized clinical trials of hyperthyroidism patients receiving LiCO3 with radioiodine compared with hyperthyroidism patients receiving radioactive iodine alone. Included studies were appraised with the risk of bias version 2 tool, according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0.ResultsNine studies were eligible for inclusion in the study, six randomized control trials and three non-randomized control trials. There were 477 patients in the intervention group and 451 patients in the control group. The cure rate was not significantly different between the two groups, while it was significantly increased with 5000 to 6500 mg optimized cumulative dose of LiCO3 compared with the control group, P = 0.0001. The T4 level showed no significant difference between the two groups, P = 0.13.ConclusionsLiCO3 adjunct to radioactive iodine did not show significant differences compared with radioactive iodine alone in terms of cure rate or decreasing T4 level. However, the dose of 5000 to 6000 mg of LiCO3 may increase the cure rate.

【 授权许可】

CC BY