Targeted exome sequencing identifies mutational landscape in a cohort of 1500 Chinese patients with non-small cell lung carcinoma (NSCLC)

Human Genomics

Chao-jun Liu¹  Li Niu¹  Ce Wang¹  Yang Ye²  Wei Zheng³  Cheng Fang⁴  Li-ming Wu⁵  Qing-hua Zeng⁶  Ya-jun Zhou⁷ 

[1] CheerLand Clinical Laboratory Co., Ltd., Building 15, Peking University Medical Industrial Park, Zhongguancun Life Science Park, 102206, Beijing, China;Department of Cardiothoracic Surgery, Jingdezhen First People’s Hospital, 33300, Jingdezhen, Jiangxi, China;Department of Oncology, PLA General Hospital, 100037, Beijing, China;Department of Oncology, The 334 Affiliated Hospital of Nanchang University, 330024, Nanchang, Jiangxi, China;Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, No.218, Jixi Road, 230022, Hefei, Anhui, China;Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi, China;Department of Thoracic Surgery, The First Affiliated Hospital of Nanchang University, 330006, Nanchang, Jiangxi, China;

关键词: Targeted exome sequencing;    Non-small cell lung carcinoma;    Chinese patients;    Cancer;    Disease;   

DOI  :  10.1186/s40246-021-00320-9

来源: Springer

【 摘 要 】

BackgroundNon-small cell lung carcinoma (NSCLC) is one of the most common human cancers, comprising approximately 80–85% of all lung carcinomas. An estimated incidence of NSCLC is approximately 2 million new cases per year worldwide.ResultsIn recent decade, the treatment of NSCLC has made breakthrough progress owing to a large number of targeted therapies which were approved for clinical use. Epidemiology, genetic susceptibility, and molecular profiles in patients are likely to play an important factor in response rates and survival benefits to these targeted treatments and thus warrant further investigation on ethnic differences in NSCLC. In this study, a total number of 1500 Chinese patient samples,1000 formalin fixed paraffin-embedded (FFPE) and 500 blood samples, from patients with NSCLC were analyzed by targeted sequencing to explore mutational landscape in ethnic groups associated with China.ConclusionsOverall, the data presented here provide a comprehensive analysis of NSCLC mutational landscape in Chinese patients and findings are discussed in the context of similar studies on different ethnic groups.

【 授权许可】

CC BY