Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

BMC Musculoskeletal Disorders

Do Kyung Kim¹  Jaeyeon Shin²  So-young Lee³  Sang-Cheol Lee⁴  Jae Hwa Kim⁴  Siyeoung Yoon⁴  Go-Tak Kim⁴  Soonchul Lee⁴  Kyung Rae Ko⁵  Hyun Il Lee⁶ 

[1] CHA Graduate School of Medicine, 120 Hyeryong-ro, 11160, Pocheon, Republic of Korea;Department of Computer Science, College of IT Engineering, SeMyung University, Semyung-ro, 27136, Jecheon-si, Chung-cheong bukdo, South Korea;Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea;Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, 13488, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea;Department of Orthopaedic Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 81 Irwon-ro, Gangnam-gu, 06351, Seoul, Republic of Korea;Department of Orthopedic Surgery, Ilsan Paik Hospital, Inje University, 10380, Goyang-si, Gyeonggi-do, Republic of Korea;

关键词: Vitamin B;    Rotator cuff;    Degenerative;    Tear;   

DOI  :  10.1186/s12891-021-04231-7

来源: Springer

【 摘 要 】

BackgroundVitamin B12 (Vit B12) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B12 levels were correlated with degenerative rotator cuff (RC) tear.MethodsEighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Possible risk factors (age, sex, medical history, bone mineral density, and serum chemistries including glucose, magnesium, calcium, phosphorus, zinc, homocysteine, Vitamin D, Vit B12, homocysteine, and folate) were assessed. Significant variables were selected based on the results of univariate analyses, and a logistic regression model (backward elimination) was constructed to predict the presence of degenerative RC tear.ResultsIn the univariate analysis, the group of patients with degenerative RC tear had a mean concentration of 528.4 pg/mL Vit B12, which was significantly lower than the healthy control group (627.1 pg/mL). Logistic regression analysis using Vit B12 as an independent variable revealed that Vit B12 concentrations were significantly correlated with degenerative RC tear (p = 0.044). However, Vit B12 levels were not associated with tear size.ConclusionLow serum levels of Vit B12 were independently related to degenerative RC tear. Further investigations are warranted to determine if Vit B12 supplementation can decrease the risk of this condition.

【 授权许可】

CC BY