BMC Research Notes | |
Circulating anti-SARS-CoV-2 nucleocapsid (N)-protein antibodies and anti-SARS-CoV-2 spike (S)-protein antibodies in an African setting: herd immunity, not there yet! | |
Guy-Stephan Padzys1  Simon Ategbo2  Eliane Kuissi Kamgaing3  Marielle Leboueny4  Joel Fleury Djoba Siawaya4  Eliode Cyrien Bongho4  Anicet Christel Maloupazoa Siawaya4  Amandine Mveang Nzoghe4  Ofilia Mvoundza Ndjindji4  Bénédicte Ndeboko5  | |
[1] Département de Biologie Cellulaire Et Physiologie, Faculté Des Sciences, Université Des Sciences Et Techniques de Masuku, Franceville, Gabon;Pôle Enfant Service de Pédiatrie, CHU- Mère-Enfant Fondation Jeanne EBORI, Libreville, Gabon;Université Des Sciences de La Santé, Libreville, Gabon;Pôle enfant, Service de Néotatologie, CHU- Mère-Enfant Fondation Jeanne EBORI, Libreville, Gabon;Université Des Sciences de La Santé, Libreville, Gabon;Service Laboratoire, Centre Hospitalier Universitaire (CHU) - Mère-Enfant), Fondation Jeanne EBORI, Libreville, Gabon;Service Laboratoire, Centre Hospitalier Universitaire (CHU) - Mère-Enfant), Fondation Jeanne EBORI, Libreville, Gabon;Université Des Sciences de La Santé, Libreville, Gabon; | |
关键词: SARS-CoV-2; Antibodies; Infants; Children; Adults; | |
DOI : 10.1186/s13104-021-05570-3 | |
来源: Springer | |
【 摘 要 】
ObjectiveHerd immunity is achieved when in a population, immune individuals are in a sufficiently large proportion. Neutralizing antibodies specific to SARS-CoV-2 that are produced following infection or vaccination are critical for controlling the spread of COVID-19. The objective of the present work was to investigate the rate of SARS-CoV-2 natural immunization in Gabonese.ResultsOne thousand, four hundred and ninety two people were enrolled. The overall prevalence of anti-SARS-CoV-2 antibodies was 36.2%. Moreover, 76.4% of people who developed a humoral response to SARS-CoV-2 produced both anti-SARS-CoV-2 N-protein antibodies and anti-SARS-CoV-2 S-protein antibodies, which correspond to 27.7% of the total population. In infants (0–9 month), children (1–17 years) and adults, the prevalence of anti-SARS-CoV-2 antibodies was relatively the same, between 33 and 37% (any antibody types) and between 25 and 28.6% (neutralizing antibodies). In this African context, one-third (1/3) of the screened population was exposed to SARS-CoV-2 and three-quarter (3/4) of those exposed individuals developed neutralizing antibodies against SARS-CoV-2. This data suggest that herd immunity is not yet to be achieved in Gabon.
【 授权许可】
CC BY
【 预 览 】
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RO202107037806529ZK.pdf | 590KB | download |