Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action

Diagnostic Pathology

Amira Mohammed Ali¹  Hiroshi Kunugi² 

[1] Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan;Department of Psychiatric Nursing and Mental Health, Faculty of Nursing, Alexandria University, Alexandria, Egypt;Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan;Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan;

关键词: Hypoproteinemia;    *albumin*;    Blood urea nitrogen;    Disease severity;    Mortality;    Coronavirus disease 2019;    COVID-19;    Multiple organ failure;    Intensive care unit;    Malnutrition;   

DOI  :  10.1186/s13000-021-01092-5

来源: Springer

【 摘 要 】

Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and multiple organ failure. The disease is associated with a hypercatabolic state that entails excessive protein loss. This review commentary sheds the light on hypoproteinemia in symptomatic/hospitalized COVID-19 with a special emphasis on its pathophysiology, screening, as well as its contribution to disease severity and adverse effects.

【 授权许可】

CC BY