期刊论文详细信息
Bioelectronic Medicine
Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation
Timir Datta-Chaudhuri1  Chad Bouton1  Justin E. Newman2  Meghan E. Addorisio2  Harold A. Silverman2  Téa Tsaava2  Emily Battinelli Masi3  Eric H. Chang4  Sangeeta S. Chavan5  Kevin J. Tracey5  Gavin H. Imperato6 
[1] Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra University, 11030, Hempstead, New York, USA;The Elmezzi Graduate School of Molecular Medicine, 350 Community Drive, 11030, Manhasset, NY, USA;Laboratory of Biomedical Science, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;Laboratory of Biomedical Science, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra University, 11030, Hempstead, New York, USA;Laboratory of Biomedical Science, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra University, 11030, Hempstead, New York, USA;Laboratory of Biomedical Science, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra University, 11030, Hempstead, New York, USA;The Elmezzi Graduate School of Molecular Medicine, 350 Community Drive, 11030, Manhasset, NY, USA;Laboratory of Biomedical Science, Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, 11030, Manhasset, NY, USA;The Elmezzi Graduate School of Molecular Medicine, 350 Community Drive, 11030, Manhasset, NY, USA;
关键词: Inflammatory reflex;    Neuromodulation;    Tumor necrosis factor;    Interleukin-10;   
DOI  :  10.1186/s42234-020-00042-8
来源: Springer
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【 摘 要 】

BackgroundElectrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacious symptomatic relief depends on the proper selection of electrical stimulation parameters to recruit the appropriate fibers within a nerve. Recently, electrical stimulation of the vagus nerve has shown promise for controlling inflammation and clinical trials have demonstrated efficacy for the treatment of inflammatory disorders. This application of vagus nerve stimulation activates the inflammatory reflex, reducing levels of inflammatory cytokines during inflammation.MethodsHere, we wanted to test whether altering the parameters of electrical vagus nerve stimulation would change circulating cytokine levels of normal healthy animals in the absence of increased inflammation. To examine this, we systematically tested a set of electrical stimulation parameters and measured serum cytokine levels in healthy mice.ResultsSurprisingly, we found that specific combinations of pulse width, pulse amplitude, and frequency produced significant increases of the pro-inflammatory cytokine tumor necrosis factor (TNF), while other parameters selectively lowered serum TNF levels, as compared to sham-stimulated mice. In addition, serum levels of the anti-inflammatory cytokine interleukin-10 (IL-10) were significantly increased by select parameters of electrical stimulation but remained unchanged with others.ConclusionsThese results indicate that electrical stimulation parameter selection is critically important for the modulation of cytokines via the cervical vagus nerve and that specific cytokines can be increased by electrical stimulation in the absence of inflammation. As the next generation of bioelectronic therapies and devices are developed to capitalize on the neural regulation of inflammation, the selection of nerve stimulation parameters will be a critically important variable for achieving cytokine-specific changes.

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