Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease

Respiratory Research

Sarah Kenny¹  Claire Healy²  Natalia Munoz-Wolf²  Seamas C. Donnelly²  Lynne Faherty²  Janné Strydom²  Niamh C. Williams²  Suzanne M. Cloonan³ 

[1] School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland;School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland;Tallaght University Hospital, Dublin, Ireland;School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland;Tallaght University Hospital, Dublin, Ireland;Joan and Sandford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York City, USA;

关键词: Nutritional immunity;    Microbiome;    Immunity;    Metals;    Iron;    COPD;    Asthma;    IPF;    Mycobacteria;   

DOI  :  10.1186/s12931-021-01722-y

来源: Springer

【 摘 要 】

Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate immune system, limiting the availability of free trace metals by cells of the immune system serves not only to conceal these vital nutrients from invading bacteria but also operates to tightly regulate host immune cell responses and function. In the setting of chronic lung disease, the regulation of trace metals by the host is often disrupted, leading to the altered availability of these nutrients to commensal and invading opportunistic pathogenic microbes. Similarly, alterations in the uptake, secretion, turnover and redox activity of these vitally important metals has significant repercussions for immune cell function including the response to and resolution of infection. This review will discuss the intricate role of nutritional immunity in host immune cells of the lung and how changes in this fundamental process as a result of chronic lung disease may alter the airway microbiome, disease progression and the response to infection.

【 授权许可】

CC BY