Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study

Eye and Vision

Barbara Mazzi¹  Ilaria Ionni¹  Michele Marinò¹  Pasquale Loiudice²  Giamberto Casini²  Michele Figus²  Marco Nardi²  Giuseppe Covello²  Marco Pellegrini³ 

[1] Department of Clinical and Experimental Medicine, Endocrinology Unit I, University Hospital of Pisa, Pisa, Italy;Department of Surgical, Ophthalmology Unit, Medical, Molecular and Critical Area Pathology, University of Pisa, Via Savi, 10, 56126, Pisa, Italy;Ophthalmology Unit, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy;

关键词: Choroidal vascularity index;    Choroidal vasculature;    Enhanced depth optical coherence tomography;    Image binarization;    Luminal area;    Subfoveal choroidal thickness;    Thyroid-associate ophthalmopathy;   

DOI  :  10.1186/s40662-021-00242-6

来源: Springer

【 摘 要 】

BackgroundHemodynamic changes have been observed in patients with Graves’ disease. The aim of our study was to evaluate choroidal vascular change using the choroidal vascularity index (CVI) in patients with thyroid-associated ophthalmopathy (TAO).MethodsIn this cross-sectional observational study, 40 patients affected by TAO were recruited. Forty healthy individuals, matched for age and sex, served as controls. Foveal enhanced-depth imaging optical coherence tomography scans were obtained from all participants. Images were binarized using the ImageJ software and luminal area (LA) and total choroidal area (TCA) were measured. CVI was calculated as the proportion of LA to TCA. The relation between CVI or subfoveal choroidal thickness (SFCT) and clinical activity score, exophthalmometric value, diplopia status, gender, and age was evaluated.ResultsCVI was significantly higher in patients with TAO (P = 0.004). No significant difference was observed in SFCT (P = 0.200) and TCA (P = 0.153) comparing TAO patients and healthy controls. LA was significantly higher in TAO group (P = 0.045). On multiple regression analysis, CVI was associated with TCA (P = 0.043). No association was found between SFCT or CVI and TCA, clinical activity score, exophthalmometric value, Inami value, diplopia status, gender or age (P > 0.05).ConclusionsThis is the first study that has demonstrated an increase in CVI in eyes with TAO compared with healthy controls and has assessed its association with clinical features.

【 授权许可】

CC BY