Current concepts in the diagnosis and management of antiphospholipid syndrome and ocular manifestations

Journal of Ophthalmic Inflammation and Infection

Neil Onghanseng¹  Diana V. Do¹  Anh N. T. Tran¹  Muhammad Hassan¹  Quan Dong Nguyen¹  Gunay Uludag¹  Muhammad Sohail Halim²  Yasir J. Sepah² 

[1] Spencer Center for Vision Research, Byers Eye Institute, Stanford University, 2370 Watson Court, Suite 200, 94303, Palo Alto, CA, USA;Spencer Center for Vision Research, Byers Eye Institute, Stanford University, 2370 Watson Court, Suite 200, 94303, Palo Alto, CA, USA;Ocular Imaging Research and Reading Center, Sunnyvale, CA, USA;

关键词: Antiphospholipid syndrome;    Antiphospholipid antibodies;    Ocular manifestations;   

DOI  :  10.1186/s12348-021-00240-8

来源: Springer

【 摘 要 】

Antiphospholipid syndrome (APS) is an autoimmune disorder associated with obstetrical complications, thrombotic complications involving both arteries and veins, and non-thrombotic manifestations affecting multiple other systems presenting in various clinical forms. Diagnosis requires the presence of antiphospholipid antibodies. The exact pathogenesis of APS is not fully known. However, it has recently been shown that activation of different types of cells by antiphospholipid antibodies plays an important role in thrombosis formation. Ocular involvement is one of the important clinical manifestations of APS and can vary in presentations. Therefore, as an ophthalmologist, it is crucial to be familiar with the ocular findings of APS to prevent further complications that can develop. Furthermore, the ongoing identification of new and specific factors contributing to the pathogenesis of APS may provide new therapeutic options in the management of the disease in the future.

【 授权许可】

CC BY