ABO blood types and sepsis mortality

Annals of Intensive Care

Jens D. Lundgren¹  Theis S. Itenov²  Sisse R. Ostrowski³  Jens-Ulrik Jensen⁴  Anne Lindhardt⁵  Mads H. Andersen⁶  Thomas Mohr⁷  Hami Tousi⁸  Lars Hein⁹  Morten H. Bestle^1,10  Christian Erikstrup^1,11  Ole B. Pedersen^1,12  Pär I. Johansson^1,13  Sofie L. Rygård^1,14  Lars B. Holst^1,14  Daniel I. Sessler^1,15  Ashish K. Khanna^1,16 

[1] CHIP / PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, The Capital Region of Denmark, Denmark;CHIP / PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, The Capital Region of Denmark, Denmark;Department of Anaesthesiology, Nordsjællands Hospital, Hillerød, Denmark;CHIP / PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, The Capital Region of Denmark, Denmark;Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;CHIP / PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, The Capital Region of Denmark, Denmark;Respiratory Section, Department of Internal Medicine, Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark;Outcomes Research Consortium, Cleveland, OH, USA;Department of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark;Department of Anaesthesiology, Aarhus University Hospital, Aarhus, Denmark;Department of Anaesthesiology, Gentofte Hospital, Hellerup, Denmark;Department of Anaesthesiology, Herlev Hospital, Copenhagen, Denmark;Department of Anaesthesiology, Nordsjællands Hospital, Hillerød, Denmark;Department of Anaesthesiology, Nordsjællands Hospital, Hillerød, Denmark;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark;Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark;Department of Clinical Immunology, Næstved Sygehus, Næstved, Denmark;Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark;Department of Intensive Care, Rigshospitalet, Denmark;Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA;Wake Forest University School of Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA;Outcomes Research Consortium, Cleveland, OH, USA;

关键词: Anaesthesia;    Blood type;    Mortality;    Sepsis;    Septic shock;    Intensive care;   

DOI  :  10.1186/s13613-021-00844-2

来源: Springer

【 摘 要 】

BackgroundWe aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1.ResultsWe included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage.ConclusionSeptic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable.

【 授权许可】

CC BY