Fulminant hepatic failure in a patient testing re-positive for SARS-CoV-2: a case report

International Journal of Emergency Medicine

Mohamed Moussa¹  Dunya Alfaraj¹  Bader Aldossary¹  Hind S. Alsaif²  Ali Hassan³ 

[1] Department of Emergency Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia;Department of Radiology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia;Department of Radiology, Salmaniya Medical Complex, Manama, Bahrain;

关键词: Case reports;    COVID-19;    Liver failure;    Re-positive test;    Re-infection;   

DOI  :  10.1186/s12245-021-00349-6

来源: Springer

【 摘 要 】

BackgroundInfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may not elicit lifelong protective immunity and reinfection could occur. Liver function impairment is a common manifestation of coronavirus disease 2019 (COVID-19). However, acute hepatic failure in the setting of COVID-19 is very rare.Case presentationWe report the case of a 47-year-old woman who presented with acute abdominal pain and vomiting. Abdominal examination revealed a soft and lax abdomen with mild tenderness in the right upper quadrant. The patient recovered from COVID-19 2 months previously with negative results on reverse transcription-polymerase chain reaction (RT-PCR). Laboratory investigations revealed markedly elevated transaminases with normal results on viral hepatitis serology panel and undetectable blood paracetamol level. Prior to admission, the patient underwent RT-PCR for SARS-CoV-2, which revealed a positive result. The patient experienced rapid deterioration in the neurological status with a remarkable increase in the liver enzyme levels. Despite aggressive resuscitation, the patient suffered irreversible cardiac arrest and died.ConclusionFulminant hepatic failure is a rare manifestation in patients with re-positive RT-PCR tests for SARS-CoV-2. Clinicians should maintain a high index of suspicion for hepatic injury with active monitoring of liver enzymes.

【 授权许可】

CC BY