Altered amygdala effective connectivity in migraine without aura: evidence from resting‐state fMRI with Granger causality analysis

The Journal of Headache and Pain

Chunmei Liu¹  Chenjie Xu²  Xiaobin Huang³  Di Zhang³  Xinying Wu³  Xindao Yin³  Zhengfei Miao³  Cunnan Mao³  Peng Wang³ 

[1] Department of Neurology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, 210006, Nanjing, Jiangsu Province, China;Department of Pain Treatment, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, 210006, Nanjing, Jiangsu Province, China;Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road Nanjing, 210006, Nanjing, Jiangsu Province, China;

关键词: Migraine;    Granger causality analysis;    Amygdala;    Pain modulation;   

DOI  :  10.1186/s10194-021-01240-8

来源: Springer

【 摘 要 】

BackgroundGranger causality analysis (GCA) has been used to investigate the pathophysiology of migraine. Amygdala plays a key role in pain modulation of migraine attack. However, the detailed neuromechanism remained to be elucidated. We applied GCA to explore the amygdala-based directional effective connectivity in migraine without aura (MwoA) and to determine the relation with clinical characteristics.MethodsForty-five MwoA patients and forty age-, sex-, and years of education-matched healthy controls(HCs) underwent resting-state functional magnetic resonance imaging (fMRI). Bilateral amygdala were used as seed regions in GCA to investigate directional effective connectivity and relation with migraine duration or attack frequency.ResultsMwoA patients showed significantly decreased effective connectivity from right amygdala to right superior temporal gyrus, left superior temporal gyrus and right precentral gyrus compared with HCs. Furthermore, MwoA patients demonstrated significantly decreased effective connectivity from the left amygdala to the ipsilateral superior temporal gyrus. Also, MwoA patients showed enhanced effective connectivity from left inferior frontal gyrus to left amygdala. Effective connectivity outflow from right amygdala to right precentral gyrus was negatively correlated to disease duration.ConclusionsAltered directional effective connectivity of amygdala demonstrated that neurolimbic pain networks contribute to multisensory integration abnormalities and deficits in pain modulation of MwoA patients.

【 授权许可】

CC BY