Cortical haemodynamic response during the verbal fluency task in patients with bipolar disorder and borderline personality disorder: a preliminary functional near-infrared spectroscopy study

BMC Psychiatry

Wilson W. Tam¹  Tong-Boon Tang²  Cyrus S. Ho³  Syeda Fabeha Husain⁴  Roger C. Ho⁴  Bach X. Tran⁵ 

[1] Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore;Centre for Intelligent Signal and Imaging Research (CISIR), University Teknologi PETRONAS, Darul Ridzuan, 32610, Seri Iskandar, Perak, Malaysia;Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, 117599, Singapore, Singapore;Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore, Singapore;Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 21205, Baltimore, MD, USA;Institute for Preventive Medicine and Public Health, Hanoi Medical University, 116001, Hanoi, Vietnam;Center of Excellence in Behavioral Medicine, Nguyen Tat Thanh University, 70000, Ho Chi Minh City, Vietnam;

关键词: Functional near-infrared spectroscopy;    Verbal fluency task;    Prefrontal cortex;    Bipolar disorder;    Borderline personality disorder;   

DOI  :  10.1186/s12888-021-03195-1

来源: Springer

【 摘 要 】

BackgroundFunctional near-infrared spectroscopy (fNIRS) is an emerging neuroimaging modality that provides a direct and quantitative assessment of cortical haemodynamic response during a cognitive task. It may be used to identify neurophysiological differences between psychiatric disorders with overlapping symptoms, such as bipolar disorder (BD) and borderline personality disorder (BPD). Hence, this preliminary study aimed to compare the cerebral haemodynamic function of healthy controls (HC), patients with BD and patients with BPD.MethodsTwenty-seven participants (9 HCs, 9 patients with BD and 9 patients with BPD) matched for age, gender, ethnicity and education were recruited. Relative oxy-haemoglobin and deoxy-haemoglobin changes in the frontotemporal cortex was monitored with a 52-channel fNIRS system during a verbal fluency task (VFT). VFT performance, clinical history and symptom severity were also noted.ResultsCompared to HCs, both patient groups had lower mean oxy-haemoglobin in the frontotemporal cortex during the VFT. Moreover, mean oxy-haemoglobin in the left inferior frontal region is markedly lower in patients with BPD compared to patients with BD. Task performance, clinical history and symptom severity were not associated with mean oxy-haemoglobin levels.ConclusionsPrefrontal cortex activity is disrupted in patients with BD and BPD, but it is more extensive in BPD. These results provide further neurophysiological evidence for the separation of BPD from the bipolar spectrum. fNIRS could be a potential tool for assessing the frontal lobe function of patients who present with symptoms that are common to BD and BPD.

【 授权许可】

CC BY