Modulating brain networks associated with cognitive deficits in Parkinson’s disease

Molecular Medicine

Iman Beheshti¹  Ji Hyun Ko² 

[1] Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave., R3E 0J9, Winnipeg, MB, Canada;Kleysen Institute for Advanced Medicine, Health Science Centre, Winnipeg, MB, Canada;Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave., R3E 0J9, Winnipeg, MB, Canada;Kleysen Institute for Advanced Medicine, Health Science Centre, Winnipeg, MB, Canada;Graduate Program in Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada;

关键词: Transcranial direct current stimulation;    Parkinson’s disease;    Cognition;    Positron emission tomography;    Functional magnetic resonance imaging;    Network analysis;    Graph theory;    Mild cognitive impairment;   

DOI  :  10.1186/s10020-021-00284-5

来源: Springer

【 摘 要 】

Parkinson’s disease (PD) is a relatively well characterised neurological disorder that primarily affects motor and cognitive functions. This paper reviews on how transcranial direct current stimulation (tDCS) can be used to modulate brain networks associated with cognitive deficits in PD. We first provide an overview of brain network abnormalities in PD, by introducing the brain network modulation approaches such as pharmacological interventions and brain stimulation techniques. We then present the potential underlying mechanisms of tDCS technique, and specifically highlight how tDCS can be applied to modulate brain network abnormality associated with cognitive dysfunction among PD patients. More importantly, we address the limitations of existing studies and suggest possible future directions, with the aim of helping researchers to further develop the use of tDCS technique in clinical settings.

【 授权许可】

CC BY