Glycemic deviation index: a novel method of integrating glycemic numerical value and variability

BMC Endocrine Disorders

Xu Hou¹  Yizhou Zou¹  Dongmei Zheng¹  Wanli Wang² 

[1] Department of Endocrinology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 324 Jing 5 Road, 250021, Jinan, China;Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China;Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, China;Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, China;School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China;

关键词: Glycemic variability;    Continuous glucose monitoring;    Diabetes;   

DOI  :  10.1186/s12902-021-00691-z

来源: Springer

【 摘 要 】

BackgroundThere are many continuous blood glucose monitoring (CGM) data-based indicators, and most of these focus on a single characteristic of abnormal blood glucose. An ideal index that integrates and evaluates multiple characteristics of blood glucose has not yet been established.MethodsIn this study, we proposed the glycemic deviation index (GDI) as a novel integrating characteristic, which mainly incorporates the assessment of the glycemic numerical value and variability. To verify its effectiveness, GDI was applied to the simulated 24 h glycemic profiles and the CGM data of type 2 diabetes (T2D) patients (n = 30).ResultsEvaluation of the GDI of the 24 h simulated glycemic profiles showed that the occurrence of hypoglycemia was numerically the same as hyperglycemia in increasing GDI. Meanwhile, glycemic variability was added as an independent factor. One-way ANOVA results showed that the application of GDI showed statistically significant differences in clinical glycemic parameters, average glycemic parameters, and glycemic variability parameters among the T2D groups with different glycemic levels.ConclusionsIn conclusion, GDI integrates the characteristics of the numerical value and the variability in blood glucose levels and may be beneficial for the glycemic management of diabetic patients undergoing CGM treatment.

【 授权许可】

CC BY